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The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which mediates both 17alpha-hydroxylase and 17,20-lyase activity in the steroid biosynthesis pathway. A T-->C polymorphism in the 5' promoter region of CYP17 has been described. To examine the association between recurrent pregnancy loss (RPL) and a polymorphism in CYP17, a case-control study of 117(More)
The etiology of recurrent pregnancy loss (RPL) remains unclear, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We examined the relation between RPL and polymorphisms in four genes, human aryl hydrocarbon (Ah) receptor, cytochrome P450 (CYP) 1A1, CYP1A2 and CYP1B1, which are involved in the(More)
  • E Kato, T Kume
  • 1980
Enterotoxigenic staphylococci (ES) were detected in 363 (34.4 %) out of 1,056 coagulase-positive isolates obtained from California Mastitis Test-positive milk from 708 cows on 168 farms scattered throughout Japan. The ES produced enterotoxins C (54.3 %), A (31.1 %), D (27.0 %) and B (10.7 %) either alone or together. None produced enterotoxin E. The ES were(More)
The purpose of the present study was to report cases of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-naïve patients carrying a mutation associated with acquired resistance to the drug. Gene alterations in 77 lung carcinoma patients were analyzed by collecting and studying curette lavage fluid at the time of diagnosis. PCRs were(More)
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