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The Immune Landscape of Cancer
TLDR
An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. Expand
Categorization of humans in biomedical research: genes, race and disease
TLDR
An epidemiologic perspective on the issue of human categorization in biomedical and genetic research that strongly supports the continued use of self-identified race and ethnicity is provided. Expand
The importance of race and ethnic background in biomedical research and clinical practice.
TLDR
With the completion of a rough draft of the human genome, some have suggested that racial classification may not be useful for biomedical studies, since it reflects “a fairly small number of genes that describe appearance” and “there is no basis in the genetic code for race. Expand
Association analysis identifies 65 new breast cancer risk loci
TLDR
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average. Expand
PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations
TLDR
A novel algorithm is presented that is effectively used for the analysis of admixed populations without having to trace the origin of individuals, and can be easily applied on large genome-wide datasets, facilitating the identification of population substructure, stratification assessment in multi-stage whole-genome association studies, and the study of demographic history in human populations. Expand
Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research.
TLDR
The historical events that led to the formation of contemporary Latino populations are reviewed and results from recent genetic and clinical studies are used to illustrate the unique opportunity Latino groups offer for studying the interaction between racial, genetic, and environmental contributions to disease occurrence and drug response. Expand
Comparing Genetic Ancestry and Self-Described Race in African Americans Born in the United States and in Africa
TLDR
The findings suggest that self-reported race and ancestry can predict ancestral clusters but do not reveal the extent of admixture, and that genetic classifications of ancestry may provide a more objective and accurate method of defining homogenous populations for the investigation of specific population-disease associations. Expand
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
TLDR
It is demonstrated that common variants in several genes in the insulin/IGF1 pathway are associated with human lifespan. Expand
Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene
TLDR
It is confirmed that rs2814778 is predictive of WBC and neutrophil count in African Americans above beyond the previously described admixture association, establishing a novel phenotype for this genetic variant. Expand
Genetic Determinants of Serum Testosterone Concentrations in Men
TLDR
A meta-analysis of genome-wide association data in 8,938 men from seven cohorts identified genetic loci significantly associated with serum testosterone concentration in men that could influence the calculation of free testosterone using law-of-mass-action equation. Expand
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