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Aquaporin-1 Channel Function Is Positively Regulated by Protein Kinase C*
TLDR
This is the first study to show that PKC positively regulates both water permeability and ionic conductance of AQP1 channels.
Deficient Zebrafish Ether-à-Go-Go-Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants
TLDR
With its molecular and pathophysiological concordance to the human arrhythmia syndrome, zebrafish reg represents the first animal model for human short-QT syndrome.
Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by α1A-adrenoceptors
TLDR
Cardiac repolarizing hERG/IKr potassium currents are modulated by α1A-adrenoceptors via PKC and PKA independently of direct channel phosphorylation, providing a link between stress and ventricular arrhythmias in patients with heart disease.
Post cardiac injury syndrome after initially uncomplicated CRT-D implantation: a case report and a systematic review
TLDR
PCIS should be considered as a rare, but serious complication of HRD implantation, may cause recurrent hospitalization and can be life threatening.
Human Cardiac Inwardly-Rectifying K+ Channel Kir2.1b Is Inhibited by Direct Protein Kinase C-Dependent Regulation in Human Isolated Cardiomyocytes and in an Expression System
TLDR
The human IK1 in atrial cardiomyocytes and one of its underlying ion channels, the Kir2.1b channel, is inhibited by PKC-dependent signal transduction pathways, possibly contributing to arrhythmogenesis in patients with structural heart disease in which PKC is activated.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents
TLDR
This work analysed acute and subacute effects of atomoxetine on cloned human Ether‐à‐Go‐Go-Go‐Related Gene (hERG) channels and found no significant differences between the reported cases of QT interval prolongation and those reported recently.
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.
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