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Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
TLDR
High levels of the chemokine receptor CX CR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer. Expand
A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression
TLDR
It is demonstrated both in vitro and in vivo that CREB controls hepatocellular carcinoma growth, supports angiogenesis, and renders resistance to apoptosis, and for the first time that in parallel to other hypoxia responsive mechanisms, CREB plays an important role in hepato Cell carcinoma tumor progression. Expand
Human erythropoietin gene therapy for patients with chronic renal failure.
TLDR
Implantation of dermal cores ex vivo transduced with human genes could eventually be used in the clinical setting to express therapeutic serum proteins like erythropoietin, but nonimmunogenic delivery system should be tested as gene vehicles. Expand
ATTENUATION OF REPERFUSION LUNG INJURY AND APOPTOSIS BY A2A ADENOSINE RECEPTOR ACTIVATION IS ASSOCIATED WITH MODULATION OF Bcl-2 AND Bax EXPRESSION AND ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED
TLDR
It is shown that in vivo activation of A2AAR confers protection against reperfusion lung injury, which is associated with decreased apoptosis and involves ERK1/2 activation and alterations in antiapoptotic Bcl-2 and proap optotic Bax proteins. Expand
Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation.
The anterior chamber of the eye is an immunologically privileged site in which allografts survive longer than at other body sites. In this regard, it is relevant that aqueous humor (AH) inhibitsExpand
Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, including Liver Regeneration.
TLDR
Hematic RF ablation induces not only a local periablational inflammatory zone but also more global proliferative effects on the liver, which could account for some of the local and distant tumor recurrence observed after treatment. Expand
Femtosecond infrared laser-an efficient and safe in vivo gene delivery system for prolonged expression.
TLDR
The femtosecond infrared titanium sapphire laser beam was developed specifically for enhancing in vivo gene delivery without risks of tissue damage and revealed that injection of 10 micro g naked DNA into the tibial muscle of mice followed by application of the laser beam resulted in the highest intensity and duration of gene expression. Expand
Activation of A3 Adenosine Receptor Provides Lung Protection Against Ischemia‐Reperfusion Injury Associated with Reduction in Apoptosis
TLDR
Even when given after the onset of ischemia, the A3AR agonist IB‐MECA conferred a powerful protection against reperfusion lung injury, which was associated with decreased apoptosis, which suggests a potentially important role for A3 AR in lung IR injury. Expand
A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion
TLDR
The results suggest not only that enhancement of the ERK pathway may shift the balance between cell death and survival toward cell survival, but also that A3 agonists have potential as an effective therapy for ischemia/reperfusion-induced lung injury. Expand
Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation.
TLDR
Liver regeneration induced by RF ablation facilitates c-met/hepatocyte growth factor axis-dependent HCC tumor formation after treatment in the MDR2 knockout model, raising the potential for therapeutic intervention to reverse this potentially deleterious tumorigenic effect. Expand
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