• Publications
  • Influence
Structure of the connexin 26 gap junction channel at 3.5 Å resolution
TLDR
The crystal structure of the gap junction channel formed by human connexin 26 (Cx26), also known as GJB2, is reported at 3.5 Å resolution, and structural determinants of solute transport through the channel are discussed.
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
TLDR
Two possible proton pathways for pumping, each spanning from the matrix to the cytosolic surfaces, were identified, including hydrogen bonds, internal cavities likely to contain water molecules, and structures that could form hydrogen bonds with small possible conformational change of amino acid side chains.
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
AcrB is a principal multidrug efflux transporter in Escherichia coli that cooperates with an outer-membrane channel, TolC, and a membrane-fusion protein, AcrA. Here we describe crystal structures of
Crystal structure of bacterial multidrug efflux transporter AcrB
TLDR
The crystal structure of AcrB implies that substrates translocated from the cell interior through the transmembrane region and from the periplasm through the vestibules are collected in the central cavity and then actively transported through the pore into the TolC tunnel.
The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process
TLDR
It is reported that the Asp-51 → Asn mutation of the bovine enzyme abolishes its proton-pumping function without impairment of the dioxygen reduction activity.
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase.
TLDR
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.35, 2.9, and 2.8 angstrom resolution, indicating the aspartate as the as partate pumping site for the O2 reduction by the enzyme.
Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A
TLDR
The high resolution three-dimensional x-ray structure of the metal sites of bovine heart cytochrome c oxidase is reported, suggesting a dinuclear copper center with an unexpected structure similar to a [2Fe-2S]-type iron-sulfur center.
Crystal Structure of the DsbB-DsbA Complex Reveals a Mechanism of Disulfide Bond Generation
TLDR
It is proposed that DsbB is converted by its specific substrate, DsbA, to a superoxidizing enzyme, capable of oxidizing this extremely oxidizing oxidase.
Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase
TLDR
The phosphatidylglycerol with vaccenate was found in CcOs of bovine and Paracoccus denitrificans, the ancestor of mitochondrion, indicating that thevaccenate is conserved in Bovine CcO in spite of the abundance of oleate.
Crystal structure of N-carbamyl-D-amino acid amidohydrolase with a novel catalytic framework common to amidohydrolases.
TLDR
DCase shows only weak sequence similarity with a family of amidohydrolases, including beta-alanine synthase, aliphatic amidases and nitrilases, but might share highly conserved residues in a novel framework, which could provide a possible explanation for the catalytic mechanism for this family of enzymes.
...
1
2
3
4
5
...