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A role for CK2 in the Drosophila circadian oscillator
It is shown that CK2β is localized within clock neurons and that the clock proteins Period and Timeless accumulate to abnormally high levels in the Andante mutant, suggesting a function for CK2-dependent phosphorylation in the molecular oscillator.
Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein.
It is shown that DBT activity is required for the phase-specific hyperphosphorylation of CLK in vivo, an event that correlates with times of maximal repression in per RNA levels, and support a conserved role for dynamic regulation of reversible phosphorylation in directly modulating the activities of circadian transcription factors.
Drosophila CLOCK Protein Is under Posttranscriptional Control and Influences Light-Induced Activity
Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca2+-Activated K+ (BKCa) Channels: Role in BKCa Trafficking to the Surface of Cultured Podocytes
It is shown by coimmunoprecipitation and GST pull-down assays that BKCa channels can associate with endogenous TRPC3 and TRPC6 channels in differentiated cells of a podocyte cell line, and this colocalization may allow them to serve as a source of Ca2+ for the activation of BK Ca channels.
A DOUBLETIME Kinase Binding Domain on the Drosophila PERIOD Protein Is Essential for Its Hyperphosphorylation, Transcriptional Repression, and Circadian Clock Function
- E. Y. Kim, H. Ko, Wangjie Yu, P. Hardin, I. Edery
- Medicine, BiologyMolecular and Cellular Biology
- 23 April 2007
These findings indicate that the binding of dPER to CLK is not sufficient for transcriptional inhibition, implicating a more indirect mode of action whereby dPER acts as a molecular bridge to “deliver” DBT and/or other factors that directly repress CLK-dependent gene expression.
The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.
ppGpp-dependent Stationary Phase Induction of Genes on Salmonella Pathogenicity Island 1*
- Miryoung Song, Hyun-ju Kim, +8 authors H. Choy
- Biology, MedicineJournal of Biological Chemistry
- 13 August 2004
We have examined expression of the genes on Salmonella pathogenicity island 1 (SPI1) during growth under the physiologically well defined standard growth condition of Luria-Bertani medium with…
Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats
- E. Bae, I. Kim, +6 authors S. Kim
- Chemistry, MedicineJournal of the renin-angiotensin-aldosterone…
- 1 December 2014
Aliskiren attenuates gentamicin-induced nephropathy by suppression of inflammatory, profibrotic and apoptotic factors through inhibition of the nuclear factor κB, Smads and mitogen-activated protein kinase signaling pathways.
REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus