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A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans
The Deleted in AZoospermia (DAZ) genes encode potential RNA-binding proteins that are expressed exclusively in prenatal and postnatal germ cells and are strong candidates for human fertility factors.Expand
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Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.
Pantothenate kinase-associated neurodegeneration (PKAN, formerly known as Hallervorden-Spatz syndrome) is a rare but devastating neurodegenerative disorder, resulting from an inherited defect inExpand
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Widespread Presence of Human BOULE Homologs among Animals and Conservation of Their Ancient Reproductive Function
Sex-specific traits that lead to the production of dimorphic gametes, sperm in males and eggs in females, are fundamental for sexual reproduction and accordingly widespread among animals. Yet theExpand
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Human BOULE gene rescues meiotic defects in infertile flies.
Defects in human germ cell development are common and yet little is known of genes required for germ cell development in men and women. The pathways that develop germ cells appear to be conservedExpand
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Association of meiotic arrest with lack of BOULE protein expression in infertile men.
Spermatogenesis is a complex developmental process of mitotic and meiotic cell divisions that ultimately results in production of haploid spermatozoa. Recent studies in flies demonstrate that theExpand
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A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.
Reproduction is required for the survival of all animals, yet few reproductive genes have been shown to have a conserved requirement for fertility across the animal kingdom. Remarkably, the RNAExpand
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Sexual antagonism and X inactivation--the SAXI hypothesis.
  • C. Wu, E. Xu
  • Biology, Medicine
  • Trends in genetics : TIG
  • 1 May 2003
X inactivation has evolved in the soma of mammalian females so that both sexes have the same ratio of X:autosomal gene expression. The X chromosome in the germ cells of XY males is also precociouslyExpand
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Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis andExpand
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The roles of the DAZ family in spermatogenesis
The DAZ family of genes are important fertility factors in animals, including humans. The family consists of Y-linked DAZ, and autosomal homologs Boule and Dazl. All three genes encode RNA-bindingExpand
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DAZL is a master translational regulator of murine spermatogenesis.
Expression of DAZ-like (DAZL) is a hallmark of vertebrate germ cells, and is essential for embryonic germ cell development and differentiation, yet the gametogenic function of DAZL has not been fullyExpand
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