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Biology of human sodium glucose transporters.
A personal review of advances in the genetics, molecular biology, biochemistry, biophysics, and structure of SGLTs, including cotransporters for sugars, anions, vitamins, and short-chain fatty acids. Expand
The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport
Membrane transporters that use energy stored in sodium gradients to drive nutrients into cells constitute a major class of proteins. We report the crystal structure of a member of the solute sodiumExpand
Renal Na(+)-glucose cotransporters.
  • E. Wright
  • Chemistry, Medicine
  • American journal of physiology. Renal physiology
  • 2001
There are at least three different candidates for these human renal Na(+)-glucose cotransporters, and this review will focus on the structure-function relationships of these three transporers, SGLT1, S GLT2, and SGLt3. Expand
Active sugar transport in health and disease
This review considers the structure and function of two premier members of the SLC5 gene family, SGLT1 and S GLT2, and their role in intestinal glucose absorption and renal glucose reabsorption and Genetics disorders of SGLTs include Glucose‐Galactose Malabsorption, and Familial Renal Glucosuria. Expand
The sodium/glucose cotransport family SLC5
The sodium/glucose cotransporter family (SLCA5) has 220 or more members in animal and bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the central nervousExpand
Intestinal absorption in health and disease--sugars.
Studies on GLUT1 null mice and Fanconi-Bickel patients suggest that there is another exit pathway for glucose and galactose that may involve exocytosis and there are no known defects of fructose absorption. Expand
Expression cloning and cDNA sequencing of the Na+/glucose co-transporter
The cloned DNA suggests that the mammalian Na+-driven transporter has no evolutionary relationship to the other sugar transporters, and no homology between the Na+/glucose co-transporter and either the mammalian facilitated glucose carrier or the bacterial sugar transport proteins. Expand
Membrane Topology of the Human Na/Glucose Cotransporter SGLT1 (*)
The model of SGLT1 secondary structure and the predicted helix ends signify information prerequisite for the rational design of further experiments on structure/function relationships, and suggest the hydrophobic C terminus forms a 14th transmembrane helix, differentiating the eukaryotic members of the S GLT1 family from bacterial homologues. Expand
Relaxation kinetics of the Na+/glucose cotransporter.
Charge transfer measurements give insight into the partial reactions of the Na+/glucose cotransporter, and, combined with genetic engineering of the protein, provide a powerful tool for studying transport mechanisms. Expand
Inhibition of Gap Junction Hemichannels by Chloride Channel Blockers
It is concluded that some chloride-channel blockers inhibit lens-connexin hemichannels by acting on a site accessible only from the extracellular space, and that drug-hemichannel interaction involves a high-affinity site other than the Ca2+ binding site. Expand