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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium. Expand
Functional profiling of the Saccharomyces cerevisiae genome
It is shown that previously known and new genes are necessary for optimal growth under six well-studied conditions: high salt, sorbitol, galactose, pH 8, minimal medium and nystatin treatment, and less than 7% of genes that exhibit a significant increase in messenger RNA expression are also required for optimal Growth in four of the tested conditions. Expand
A genome-wide transcriptional analysis of the mitotic cell cycle.
The genome-wide characterization of mRNA transcript levels during the cell cycle of the budding yeast S. cerevisiae indicates a mechanism for local chromosomal organization in global mRNA regulation and links a range of human genes to cell cycle period-specific biological functions. Expand
Replication dynamics of the yeast genome.
Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication. Expand
Large-scale identification of single-feature polymorphisms in complex genomes.
A high-throughput genotyping platform is developed by hybridizing genomic DNA from Arabidopsis thaliana accessions to an RNA expression GeneChip (AtGenome1), and it is demonstrated that array hybridization can be combined with bulk segregant analysis to quickly map mutations. Expand
Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
A high-density oligonucleotide array is used to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle and finds genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes. Expand
Genomics, gene expression and DNA arrays
Measurements of gene expression and other applications of arrays embody much of what is implied by the term ‘genomics’; they are broad in scope, large in scale, and take advantage of all available sequence information for experimental design and data interpretation in pursuit of biological understanding. Expand
The core meiotic transcriptome in budding yeasts
- M. Primig, Roy M. Williams, +5 authors R. E. Esposito
- Biology, Medicine
- Nature Genetics
- 1 December 2000
High-density oligonucleotide microarrays were used to analyse the genomes and meiotic expression patterns of two yeast strains that display distinct kinetics and efficiencies of sporulation and yielded approximately 1,600 meiotically regulated genes in each strain. Expand
Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes
It is shown that switching from sialic acid–dependent to –independent invasion is reversible and depends on parasite ligand use, and differential activation of PfRh4 represents a previously unknown mechanism to switch invasion pathways and provides P. falciparum with exquisite adaptability in the face of erythrocyte receptor polymorphisms and host immune responses. Expand
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.
- J. A. Young, Q. L. Fivelman, +6 authors E. Winzeler
- Biology, Medicine
- Molecular and biochemical parasitology
- 1 September 2005
Light is shed on the components of molecular mechanisms underlying parasite sexual development and other areas of malarial parasite biology by applying a novel knowledge-based data-mining algorithm termed ontology-based pattern identification (OPI). Expand