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Proximal location of mouse prostate epithelial stem cells
Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouseExpand
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Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue.
We previously showed that prostatic stem cells are concentrated in the proximal regions of prostatic ducts. We now report that these stem cells can be purified from isolated proximal duct regions byExpand
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TGF-β maintains dormancy of prostatic stem cells in the proximal region of ducts
We have previously shown that prostatic stem cells are located in the proximal region of mouse prostatic ducts. Here, we show that this region responds differently to transforming growth factorExpand
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Tobacco smoking in seven Latin American cities: the CARMELA study
Objective This study aimed to explore tobacco smoking in seven major cities of Latin America. Methods The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study is aExpand
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High Aldehyde Dehydrogenase Activity: A Novel Functional Marker of Murine Prostate Stem/Progenitor Cells
We have shown previously that prostatic stem/progenitor cells can be purified from isolated prostate ducts, based on their high expression of the Sca‐1 surface antigen. We now report that high levelsExpand
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Proximal Prostatic Stem Cells Are Programmed to Regenerate a Proximal‐Distal Ductal Axis
Prostate carcinoma and benign prostatic hypertrophy may both originate in stem cells, highlighting the importance of the characterization of these cells. The prostate gland contains a network ofExpand
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Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells
The vasculature of the prostate responds to androgens. Androgens most likely affect the vasculature indirectly by modulating the expression of angiogenic factors in the cells of the prostate. MostExpand
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Differentiation and stromal‐induced growth promotion of murine prostatic tumors
We have derived a panel of p53‐null prostatic “basal” and “luminal” epithelial cell lines and their ras transformed counterparts to study stromal/epithelial interactions and the properties of tumorsExpand
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Stromal/epithelial interactions of murine prostatic cell lines in vivo: A model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
One of the major constraints in elucidating the mechanisms involved in the etiology of benign prostatic hyperplasia (BPH) is the lack of suitable model systems that are readily manipulable in vitroExpand
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Solution or reduction of equilibrium equations for large complex structural systems
The numerical method is based on active column method in which the stiffness matrix is stored in compacted block form on secondary storage. Expand
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