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The radiation response of the cervical spinal cord of the pig: effects of changing the irradiated volume.
TLDR
No significant field size-related differences in response were detectable in the cervical spinal cord of mature pigs after single dose irradiations, specifically at a clinically relevant level of effect (< ED10). Expand
Boron neutron capture irradiation of the rat spinal cord: histopathological evidence of a vascular-mediated pathogenesis.
TLDR
A histopathological study was carried out on the spinal cords of rats after boron neutron capture (BNC) irradiation, finding damage to the vascular endothelium results in the development of the lesions seen in the spinal cord after BNC irradiation and, by inference, after irradiation with more conventional modalities. Expand
Capillary endothelium. Target site of renal radiation injury.
TLDR
It is concluded that endothelial cell injury represents the primary site of radiation damage in the kidney and that the progressive glomerular mesangial sclerosis and reduced renal function of radiation nephropathy may be associated with exposure of capillary elements to various vasoactive and growth promoting factors that stimulate mesangIAL contraction and proliferation resulting in reduced glomerULAR filtration area and glomerul filtrations rate. Expand
Microvasculature and radiation damage.
TLDR
There is sufficient evidence to implicate the slowly dividing cells in the walls of blood vessels as the target cell populations in the pathogenesis of late radiation effects, leading to the amelioration ofLate radiation damage in normal tissues. Expand
Influence of a low protein diet on radiation nephropathy in the pig.
TLDR
Dairy protein restriction appears to reduce some of the signs of radiation nephropathy in the pig, and radiation-induced reduction in mean individual kidney GFR, effective renal plasma flow, and the haematocrit were serially measured before and up to 20 weeks after irradiation. Expand
Boron neutron capture therapy: a guide to the understanding of the pathogenesis of late radiation damage to the rat spinal cord.
TLDR
The histopathological observations of the present study support the hypothesis that the blood vessels, and the endothelial cells in particular, are the critical target population responsible for the lesions seen in the spinal cord after BNCT type irradiation and by inference, after more conventional irradiation modalities such as photons or fast neutrons. Expand
A new model of radiation-induced myelopathy: a comparison of the response of mature and immature pigs.
TLDR
A reliable experimental model of radiation-induced myelopathy has been developed for mature pigs and is suitable for the study of clinically relevant volume effects. Expand
A morphological study of radiation nephropathy in the pig.
TLDR
Findings indicate that (a) there is no one target or dose-limiting cell, and (b) the vasculature does not play a primary role in the development of radiation nephropathy. Expand
Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids.
TLDR
Essential fatty acids can modulate normal tissue reactions when given over the time when radiation damage is normally expressed, and suggest that a > or = 10% higher dose is required to produce the same level of normal tissue injury. Expand
Sequential evaluation of radiation-induced glomerular ultrastructural changes in the pig kidney.
TLDR
Renal irradiation resulted in a progressive decline in GFR, ERPF, and Hct, with minimal values being observed within 12 weeks of irradiation, and mesangial cells exhibited evidence of activation and proliferation accompanied by progressive mesangia expansion and sclerosis. Expand
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