Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
The effect of Cl-F-ara-ATP on human DNA polymerases alpha, beta, and gamma isolated from K562 cells grown in culture was determined and compared with those ofCl-dATP and 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate (F-ARA-ATp).
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.
Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase.
Antituberculosis activity of the molecular libraries screening center network library.
Slow Polymerization of Mycobacterium tuberculosis FtsZ
- E. White, L. Ross, R. Reynolds, Lainne E. Seitz, Georgia D. Moore, D. Borhani
- BiologyJournal of Bacteriology
- 15 July 2000
SRI 7614, an inhibitor of tubulin polymerization synthesized at Southern Research Institute, inhibits M. tuberculosis FtsZ polymerization, inhibits GTP hydrolysis, and reduces the number and sizes of FTSZ polymers.
Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals.
Unique Anti-Human Immunodeficiency Virus Activities of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide, and Dihydrocostatolide
Comparison of cross-resistance data obtained with a panel of NNRTI-resistant virus strains suggests that a compound of the calanolide A series, such as costatolide, should be evaluated further for therapeutic use in combination with other anti-HIV agents.
Discovery of a novel inhibitor of kinesin-like protein KIFC1.
SR31527 prevented bipolar clustering of extra centrosomes in triple negative breast cancer (TNBC) cells and significantly reduced TNBC cell colony formation and viability, but was less toxic to normal fibroblasts.
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.
- E. White, W. J. Suling, L. Ross, Lainne E. Seitz, R. Reynolds
- Biology, ChemistryJournal of Antimicrobial Chemotherapy
- 1 July 2002
Two compounds, Sri-3072 and SRI-7614, inhibited FtsZ polymerization and were equipotent against susceptible and single-drug-resistant strains of M. tuberculosis.