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Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects.
ABSTRACT Plasma cortisol was measured for seven 24-hr periods using the frequent sampling technique (every 20 min) in 6 normal acclimated subjects. A defined sleep-wake schedule was established overExpand
Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.
We describe a new syndrome called "delayed sleep phase insomnia." Thirty of 450 patients seen for a primary insomniac complaint had the following characteristics: (1) chronic inability to fall asleepExpand
Human sleep: its duration and organization depend on its circadian phase.
Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleepExpand
Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia.
We report here the development of a brief drug-free rescheduling treatment ("chronotherapy") for Delayed Sleep Phase (DSP) insomnia, a syndrome characterized by sleep-onset insomnia with difficultyExpand
Mathematical model of the human circadian system with two interacting oscillators.
Human subjects during extended isolation from environmental time cues show complex variations in timing and duration of sleep with a progressive pattern, which eventually results in rest-activity andExpand
Periodic movements in sleep (nocturnal myoclonus): Relation to sleep disorders
Periodic movements in sleep (PMS) are stereotyped, repetitive, nonepileptiform movements of the lower extremities. A total of 409 sleep disorder patients were studied with all‐night polysomnogramExpand
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Studies were carried out on a group of six young (ages 23-30) and six older (ages 53-70) normal men who lived under conditions of temporal, but not social isolation, from three to eight weeks. DuringExpand
Sleep-wake disorders based on a polysomnographic diagnosis. A national cooperative study.
Under the organizational aegis of Project Sleep and the Association of Sleep Disorders Centers (ASDC), nearly 5,000 patient records from 11 sleep-wake disorders clinics were analyzed in a cooperativeExpand
Electroencephalography (EEG) of Human Sleep: Clinical Applications
This monograph describes the normative pattern of electroencephalographic and polygraphic physiological recording of normal human nocturnal sleep and represents work carried out in the authors'Expand
ACTH and cortisol secretory patterns in man.
Plasma concentrations of ACTH (by radioimmunoassay) and cortisol (by competitive protein binding) were measured in a normal man at 5-min intervals from 0100 to 0900 hr. During this time there were 18Expand