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Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects.
- E. Weitzman, D. Fukushima, C. Nogeire, H. Roffwarg, T. Gallagher, L. Hellman
- BiologyThe Journal of clinical endocrinology and…
- 1 July 1971
Although great variability was found in both the amount of cortisol secreted and the time spent in secretory activity/hr, the secretory rate was quite constant at approximately .05 mg/min.
Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.
A new syndrome called "delayed sleep phase insomnia" is described, which is proposed to be a disorder of the circadian sleep-wake rhythm in which the "advance" portion of the phase response curve is small.
Human sleep: its duration and organization depend on its circadian phase.
- C. Czeisler, E. Weitzman, M. Moore-Ede, J. C. Zimmerman, R. Knauer
- Psychology, BiologyScience
- 12 December 1980
Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep…
Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia.
A brief drug-free rescheduling treatment for Delayed Sleep Phase insomnia, a syndrome characterized by sleep-onset insomnia with difficulty in morning awakening, which was designed to reset patients' biological clocks by the phase delay route.
Periodic movements in sleep (nocturnal myoclonus): Relation to sleep disorders
The results suggest that although PMS is responsible for disturbed sleep in relatively few patients, chronic sleep‐wake disturbance is associated with PMS and may lead to the development of these movements.
Mathematical model of the human circadian system with two interacting oscillators.
- R. Kronauer, C. Czeisler, S. Pilato, M. Moore-Ede, E. Weitzman
- BiologyThe American journal of physiology
A model where temperature and rest-activity are each governed by an oscillator of the van der Pol type, denoted x and y, respectively, finds that the entire pattern sequence can be realistically reproduced by causing only the intrinsic period of the y oscillator to increase while that of x remains stable.
Electroencephalography (EEG) of Human Sleep: Clinical Applications
- E. Weitzman
- 4 November 1974
The authors find a significant and consistent difference of sleep stage patterns between men and women from puberty through age 70 and one chapter that discusses present concepts of disorders of sleep.
Sleep-wake disorders based on a polysomnographic diagnosis. A national cooperative study.
Under the organizational aegis of Project Sleep and the Association of Sleep Disorders Centers (ASDC), nearly 5,000 patient records from 11 sleep-wake disorders clinics were analyzed in a cooperative study, and the most prevalent diagnoses were sleep apnea and narcolepsy.
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Timing of REM sleep is coupled to the circadian rhythm of body temperature in man.
- C. Czeisler, J. C. Zimmerman, J. Ronda, M. Moore-Ede, E. Weitzman
- Biology, PsychologySleep
- 1 September 1980
There is an endogenous circadian rhythm of REM sleep propensity which is closely coupled to the body temperature rhythm and is capable of free-running with a period different from both 24 hr and the average period of the sleep-wake cycle.