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Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.
Summary Forty-one food additives and 20 chemotherapeutic agents were examined for their ability to induce primary lung tumors in A mice. The animals received i.p. injections of each compound for 8Expand
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Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity.
Twenty-one aromatic amines or derivatives were tested for long-term toxicity by dietary administration to male Charles River rats and male and female HaM/lCR mice. 2,4-Toluenediamine,Expand
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Carcinogenicity tests of certain environmental and industrial chemicals.
Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats. Under the conditions of the tests, propane sultone, propylene imine,Expand
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Chemistry, carcinogenicity, and metabolism of 2-fluorenamine and related compounds.
Publisher Summary This chapter describes the chemistry, carcinogenicity, and metabolism of 2-flurorenamine and related compounds. It discusses the synthesis and chemistry of fluorenamine compoundsExpand
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Spontaneous tumors in Sprague-Dawley rats and Swiss mice.
Summary A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used asExpand
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Aging changes in CD-1 HaM/ICR mice reared under standard laboratory conditions.
Three hundred CD-1 HaM/ICR mice were observed for 2 years, and useful necropsies were done on 99 males and 102 females. Mortality was 50% at 16 months in the males and 18 months in the females. AmongExpand
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Metabolism and activation of chemical carcinogens
  • E. Weisburger
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
  • 15 September 1980
SummaryA great deal of effort has gone into research on the mechanisms of action of chemical carcinogens. The action of the host on the carcinogen represents one approach — to determine whatExpand
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Ethylene dichloride: the influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats.
Male and female Sprague-Dawley rats were exposed to 50 ppm ethylene dichloride (EDC) for 7 hr/day, 5 days/week, for 2 years by inhalation. Additional rats were exposed to 50 ppm EDC either with 0.05%Expand
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Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.
In the past most metabolic reactions on exogenous materials were considered to be detoxification reactions. However, during investigations on adverse effects of aromatic amines and related materials,Expand
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Isolation and long-term cell culture of epithelial-like cells from rat liver.
Abstract Epithelial-like cells from livers of 10-day-old rats were separated from fibroblast-like cells on the basis of differential attachment to a culture surface. After further elimination ofExpand
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