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The role of oxidative stress in chemical carcinogenesis.
- J. Klaunig, Y. Xu, +5 authors E. Walborg
- Biology, Medicine
- Environmental health perspectives
- 1 February 1998
A potential role for oxidative-induced injury in the cancer process specifically during the promotion stage is supported and the effect of nongenotoxic carcinogens may be amplified in rodents but not in primates because of rodents' greater sensitivity to ROS. Expand
Effect of transport stress on respiratory disease, serum antioxidant status, and serum concentrations of lipid peroxidation biomarkers in beef cattle.
- N. Chirase, L. W. Greene, +7 authors J. Klaunig
- Biology, Medicine
- American journal of veterinary research
- 1 June 2004
Transport stress increases serum concentrations of oxidative stress biomarkers that are related to episodes of bovine respiratory disease and mortality in calves. Expand
Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats.
- K. Kolaja, D. E. Stevenson, J. T. Johnson, E. Walborg, J. Klaunig
- Fundamental and applied toxicology : official…
The lack of an increase in serum enzymes indicative of hepatic damage and the absence of liver histopathology in mice or rats fed dieldrin or phenobarbital indicate that the induction of DNA synthesis was not mediated by a cytolethal, compensatory hyperplastic response, suggesting a mitogenic mechanism. Expand
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Comparisons showed that PB at doses of 100 and 500 mg/kg diet promoted focal hepatic lesion growth both by increasing DNA synthesis and cell proliferation and by decreasing the rate of apoptosis. Expand
Establishment of a transplantable ascites variant of a rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene.
A transplantable ascites variant, designated AS-30D, has been established from a 3′-methyl-4-dimethylaminoazobenzene-induced rat hepatoma, which produces a high yield of tumor cells which can be obtained essentially free of nontumor cells and connective tissue. Expand
Monograph: reassessment of human cancer risk of aldrin/dieldrin.
It is proposed that the most appropriate cancer risk descriptor for aldrin/dieldrin, relating to the mouse liver tumor response, is 'not likely a human carcinogen', a descriptor consistent with the example of phenobarbital cited by EPA. Expand
Reversibility of promoter induced hepatic focal lesion growth in mice.
Data indicate that induction and maintenance of the growth of some preneoplastic lesions in the mouse may be dependent upon continuous tumor promoter treatment. Expand
Identification of dipeptidyl peptidase IV as a protein shared by the plasma membrane of hepatocytes and liver biomatrix.
Data indicate that Hep105 s a peptide component of DPPIV, and Staphylococcus aureus V8 protease yielded essentially identical patterns of 125I-labeled peptide degradation products, indicating that Hep 105 and Hep150 are structurally related. Expand
Role of oxidative stress in the mechanism of dieldrin's hepatotoxicity.
- S. Bachowski, K. Kolaja, +4 authors J. Klaunig
- Biology, Medicine
- Annals of clinical and laboratory science
- 1 May 1997
It was found that dieldrin induced oxidative stress in the mouse but not the rat, and the observed oxidative stress correlated with the induction of DNA S-phase synthesis, which suggests thatThe induction of oxidative stress may be a mechanism by which d yieldrin and other mouse specific compounds selectively induce their hepatic toxic effects in mice. Expand
High‐affinity triplex‐forming oligonucleotide target sequences in mammalian genomes
It is possible to target the majority of human and mouse genes with specific TFOs, and many genes involved in mammalian cell proliferation and carcinogenesis can now be targeted. Expand