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Haloacetonitriles vs. regulated haloacetic acids: are nitrogen-containing DBPs more toxic?
TLDR
Using microplate-based Chinese hamster ovary cell assays for chronic cytotoxicity and acute genotoxicity, HANs were analyzed and the rank order of declining genotoxic rank order was IAN > BAN approximately DBAN > BCAN > CAN > TCAN > DCAN.
Occurrence and mammalian cell toxicity of iodinated disinfection byproducts in drinking water.
TLDR
In general, compounds that contain an iodo-group have enhanced mammalian cell cytotoxicity and genotoxicity as compared to their brominated and chlorinated analogues.
Halonitromethane drinking water disinfection byproducts: chemical characterization and mammalian cell cytotoxicity and genotoxicity.
TLDR
This research demonstrated the integration of the procedures for the analytical chemistry and analytical biology when working with limited amounts of sample and found the brominated nitromethanes were more cytotoxic and genotoxic than their chlorinated analogues.
Chemical and biological characterization of newly discovered iodoacid drinking water disinfection byproducts.
TLDR
IA is the most toxic and genotoxic DBP in mammalian cells reported in the literature, and data suggest that chloraminated drinking waters that have high bromide and iodide source waters may contain these iodoacids and most likely other iodo-DBPs.
Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproducts.
TLDR
With the exception of brominated trihaloacetamides, most of the toxicity rank order was consistent with structure-activity relationship expectations and the presence of at least one good leaving halogen group appears to be critical for significant toxic activity.
Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by‐products
TLDR
The microplate CHO cell cytotoxicity and genotoxicity assays were well suited for the analysis of DBPs, especially when the quantity of test material is limited, and it was determined that the DBP genotoxic potency in CHO cells and the mutagenic potency in S. typhimurium were not related.
Comparative mammalian cell toxicity of N-DBPs and C-DBPs
TLDR
A quantitative, direct comparison amongst classes of drinking water disinfection by-products (DBPs), developed and calibrated in vitro mammalian cell cytotoxicity and genotoxicity assays to integrate the analytical biology with the analytical chemistry of these important environmental contaminants demonstrate the universality of the comparative toxicity of iodo- > bromo- » chloro-DBPs.
Formation of toxic iodinated disinfection by-products from compounds used in medical imaging.
TLDR
While ICM are not toxic in themselves, their presence in source waters may be a source of concern because of the formation of highly toxic iodo-DBPs in chlorinated and chloraminated drinking water.
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