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The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system.
The activation of SNS during an immune response might be aimed to localize the inflammatory response, through induction of neutrophil accumulation and stimulation of more specific humoral immune responses, although systemically it may suppress Th1 responses, and, thus protect the organism from the detrimental effects of proinflammatory cytokines and other products of activated macrophages. Expand
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
The results suggest that cannabinoid-mediated modulation of hippocampal interneuron networks operate largely via presynaptic receptors on CCK-immunoreactive basket cell terminals, the likely mechanism by which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and associated cognitive functions. Expand
CD39 and CD73 in immunity and inflammation.
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders. Expand
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.
It is demonstrated that adenosine receptor stimulation differentially modulates the LPS-induced production of IL-10, TNF-alpha, and NO in vitro and in vivo. Expand
P2X7 receptors in the nervous system
Since they may play a prominent role in certain neurologic disorders, such as ischemia-reperfusion injury, Alzheimer's disease, spinal cord injury and sensory neuropathies, the pathological role and potential therapeutic exploitation of P2X(7) receptors are discussed. Expand
Nitric oxide: a novel link between synaptic and nonsynaptic transmission
The effect of NO on transporters represents a new form of interneuronal communication, a nonsynaptic interaction without receptors, which might be nonsynaptically signaled to the surrounding monoaminergic neurons. Expand
Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes
A high-resolution, acousto-optic two-photon microscope with continuous three-dimensional trajectory and random-access scanning modes that reaches near-cubic-millimeter scan range and can be adapted to imaging different spatial scales is developed. Expand
Adenosine Augments IL-10 Production by Macrophages through an A2B Receptor-Mediated Posttranscriptional Mechanism1
It is demonstrated that adenosine receptor occupancy increasesIL-10 production by LPS-stimulated macrophages without affecting IL-10 promoter activity and IL- 10 mRNA levels, indicating a posttranscriptional mechanism. Expand
A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli.
The results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 production after bacterial infection, and that TRAF6 impairs the potentiating effect of adenosine. Expand
Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system.
  • E. Vizi
  • Biology, Medicine
  • Pharmacological reviews
  • 1 March 2000
The role of nonsynaptic receptors and transporters in presynaptic modulation of chemical transmission in the central nervous system is reviewed and it will be suggested for the first time that the receptors andTransporters expressed nonsynaptically and being of high affinity are the target of drugs taken by the patient. Expand