Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.
Transfusion greatly reduces the risk of a first stroke in children with sickle cell anemia who have abnormal results on transcranial Doppler ultrasonography.
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.
Adult patients taking hydroxyurea for frequent painful sickle cell episodes appear to have reduced mortality after 9 of years follow-up, and indications for hydroxyUREa treatment should be expanded.
Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease.
Until safe and effective preventive strategies against infarct recurrence are discovered, MRI studies are best reserved for children with neurologic symptoms, neuropsychometric deficits, or elevated cerebral artery velocities.
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Course
In children, ACS was milder and more likely due to infection, whereas in adults ACS was severe, associated with pain and had a higher mortality rate, which was four times higher in adults than in children.
Pulmonary complications of sickle cell disease.
From the Division of Pulmonary, Allergy, and Critical Care Medicine and the Hemostasis and Vascular Biology Research Institute, University of Pittsburgh, Pittsburgh, (M.T.G.); and Children’s Hospital…
Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent.
- S. Singer, V. Wu, R. Mignacca, F. Kuypers, P. Morel, E. Vichinsky
- Medicine, BiologyBlood
- 15 November 2000
AlloIMmunization and autoimmunization are common, serious complications in Asian thalassemia patients, who are affected by donor-recipient RBC antigen mismatch and immunological factors.
Sickle cell disease
SCD is characterized by a remarkable phenotypic complexity; common acute complications are acute pain events, acute chest syndrome and stroke; chronic complications (including chronic kidney disease) can damage all organs.
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group.
Among patients with sickle cell disease, the acute chest syndrome is commonly precipitated by fat embolism and infection, especially community-acquired pneumonia, and among older patients and those with neurologic symptoms, the syndrome often progresses to respiratory failure.
Using qualitative and quantitative strategies to evaluate knowledge and perceptions about sickle cell disease and sickle cell trait.
- M. Treadwell, Lakenya McClough, E. Vichinsky
- MedicineJournal of the National Medical Association
- 1 May 2006
Despite a screening history in the 1970s fraught with controversy, sickle cell disease management and detection can be a model for the empowerment of communities in making informed decisions about theirs and their families' futures, given the burgeoning of genetic information.
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.
Voxelotor significantly increased hemoglobin levels and reduced markers of hemolysis in this phase 3 randomized, placebo-controlled trial involving participants with sickle cell disease, consistent with inhibition of HbS polymerization and indicate a disease-modifying potential.