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Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin.
Resveratrol increased GLUT-4 expression and reduced endothelin expression and cardiac apoptosis in ischemic-reperfused hearts in the presence or absence of glucose intake in Zucker obese rats. Expand
The protective effect of EGb 761 in isolated ischemic/reperfused rat hearts: a link between cardiac function and nitric oxide production.
The findings show that EGb 761 directly acts as an NO scavenger and concomitantly inhibits the expression of iNOS mRNA, and may act as a potent inhibitor of NO production under the condition of ischemia/reperfusion, improving the recovery of postischemic cardiac function. Expand
Heme oxygenase-1-related carbon monoxide and flavonoids in ischemic/reperfused rat retina.
Sour cherry seed flavonoid-rich extract showed a protective effect against reperfusion-induced injury through its ability to reduce the changes in concentrations of retinal ions through HO-1-related endogenous CO production in the ischemic/reperfused retina. Expand
Non-specific caspase inhibition reduces infarct size and improves post-ischaemic recovery in isolated ischaemic/reperfused rat hearts
It is concluded that non-specific inhibition of caspases may be therapeutically beneficial in myocardial ischaemia/reperfusion-induced damage, while selective caspase inhibitors may fail to prevent such reperfusions-induced injury in the model system. Expand
Heme oxygenase‐1 related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium
Interventions that are able to increase endogenous CO may prevent the development of VF, as reflected in the HO‐1‐related endogenous CO production measured by gas chromatography. Expand
Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts.
Immunohistochemistry indicates that a reduction in caspase-3 activity and apoptotic cells by the extract could be responsible for the cardioprotection in ischemic-reperfused myocardium. Expand
Isolation and analysis of bioactive constituents of sour cherry (Prunus cerasus) seed kernel: an emerging functional food.
The results show that sour cherry seed kernel oil contains vegetable oils including unsaturated fatty acids, oleic acids, alpha-tocopherol, tocotrienols, and tocopherol-like components, which could have useful therapeutic effects in the prevention of various vascular diseases. Expand
Heme oxygenase and cardiac function in ischemic/reperfused rat hearts.
The data show that the mechanism(s) of ischemia/reperfusion-induced VF involves the downregulation of HO-1 mRNA and a reduction in HO activity, which does not show a significant difference between nondiabetics and diabetics. Expand
Inhibition of ischemia/reperfusion-induced damage by dexamethasone in isolated working rat hearts: the role of cytochrome c release.
The results suggest that the inhibition of cytochrome c release is involved in the dexamethasone-induced cardiac protection and significantly reduces the occurrence of ventricular fibrillation. Expand
[The protective effect of EGb 761 in isolated isochemical/reperfused rat hearts].
  • E. Varga
  • Chemistry, Medicine
  • Acta pharmaceutica Hungarica
  • 2002
Findings show that EGb 761 directly acts as an NO scavenger and concomitantly inhibits the expression of iNOS mRNA, improving the recovery of postischemic cardiac function. Expand