• Publications
  • Influence
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
The release of adenosine triphosphate through autophagy can promote antitumor immune responses. Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thusExpand
  • 842
  • 55
Consensus guidelines for the detection of immunogenic cell death
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger aExpand
  • 417
  • 26
  • PDF
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell–mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulateExpand
  • 472
  • 23
Regulation of autophagy by cytosolic acetyl-coenzyme A.
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion ofExpand
  • 265
  • 13
Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Cardiac glycosides kill cancer cells in a way that stimulates the immune response. A Cancer Double Feature—3807 A traditional chemotherapeutic drug performs a one-act play: It enters and kills aExpand
  • 229
  • 13
  • PDF
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.
The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells,Expand
  • 377
  • 12
Classification of current anticancer immunotherapies
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food andExpand
  • 258
  • 10
  • PDF
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, includingExpand
  • 184
  • 10
  • PDF
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRMExpand
  • 181
  • 8
Trial watch
Solid tumors are constituted of a variety of cellular components, including bona fide malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor stroma exerts majorExpand
  • 152
  • 8