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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
The release of adenosine triphosphate through autophagy can promote antitumor immune responses. Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus… Expand
Consensus guidelines for the detection of immunogenic cell death
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a… Expand
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell–mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate… Expand
Regulation of autophagy by cytosolic acetyl-coenzyme A.
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion of… Expand
Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
- L. Menger, E. Vacchelli, +18 authors G. Kroemer
- Biology, Medicine
- Science Translational Medicine
- 18 July 2012
Cardiac glycosides kill cancer cells in a way that stimulates the immune response. A Cancer Double Feature—3807 A traditional chemotherapeutic drug performs a one-act play: It enters and kills a… Expand
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.
The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells,… Expand
Classification of current anticancer immunotherapies
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and… Expand
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including… Expand
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM… Expand
Solid tumors are constituted of a variety of cellular components, including bona fide malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor stroma exerts major… Expand