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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes,, the nature of the ‘help’ provided to CTLs is unknown. One widely…
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
Findings indicate that the CD40–CD40 ligand pair can act as a 'switch', determining whether naive peripheral CTLs are primed or tolerized, and support the clinical use of CD40-stimulating agents as components of anti-cancer vaccines.
Creation of immune ‘stealth’ genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1
It is demonstrated how the GAr domain can be exploited to create immuno‘stealth’ genes by hiding transgene products from CTL-mediated immune attack by preventing recognition of GAr-LacZ-expressing cells by β-galactosidase-specific CTL.
Characterization of an immuno ‘stealth’ derivative of the herpes simplex virus thymidine-kinase gene
- M. Ossevoort, A. Zaldumbide, S. Cramer, E. V. D. Voort, R. Toes, R. Hoeben
- BiologyCancer Gene Therapy
- 1 June 2006
A new optimized derivative of the herpes simplex virus 1-thymidine-kinase (HSV1-TK) gene is described, which may be especially useful in those gene therapy applications where an immune response against the transgene-encoded product would frustrate the treatment.
Targeting FLT 3 in primary MLL-gene – rearranged infant acute lymphoblastic leukemia
FLT3 expression in infants with MLL is demonstrated to be significantly higher compared to both infant and noninfant patients with ALL, suggesting that infant MLL cells displaying activated FLT3 as a result of overexpression can be targeted by FLT 3 inhibitors such as PKC412.
SAT0029 THE IMMUNE-PATHOGENIC CHARACTERISTICS OF AUTOREACTIVE B CELLS AGAINST CITRULLINATED ANTIGENS IN RHEUMATOID ARTHRITIS
These findings provide first evidence that ACPA-expressing B cells are well equipped to activate T cells, actively differentiate into IL-8 producing plasmablasts and, hence, could attract neutrophils to the rheumatoid joint.
Lymphocytes T + Captured in Immune Complexes to CD 8 Augmenting the Presentation of Antigen A Novel Role of Complement Factor C 1 q in
Nephritis and dermatitis in systemic lupus erythematosus sle are strongly associated with the occurrence of igg autoantibodies c1qab against the first subcomponent of complement
Immunity Versus Tolerance Factors in the Balance Between CTL Activation Status of APC Are Decisive Longevity of Antigen Presentation and
A5.29 Spontaneous Production of Anti-Citrullinated Protein Antibodies in Cultures of Peripheral Blood Mononuclear Cells and Synovial Fluid Mononuclear Cells Isolated from Patients with Rheumatoid…
ACPA specific plasmablasts circulate in the peripheral blood of patients with ACPA positive RA, and this observation suggests that ACPA specific B cells are either continuously recruited from the memory compartment, or that a subset of ACPAspecific plasmacells might have the capacity to survive for extended periods of time.