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Composition and Hierarchical Organisation of a Spider Silk
Albeit silks are fairly well understood on a molecular level, their hierarchical organisation and the full complexity of constituents in the spun fibre remain poorly defined. Here we linkExpand
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Transport of Beads by Several Kinesin Motors
The movements of beads pulled by several kinesin-1 (conventional kinesin) motors are studied both theoretically and experimentally. While the velocity is approximately independent of the number ofExpand
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Characterization of the protein components of Nephila clavipes dragline silk.
Spider silk is predominantly composed of structural proteins called spider fibroins or spidroins. The major ampullate silk that forms the dragline and the cobweb's frame threads of Nephila clavipesExpand
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Differential polymerization of the two main protein components of dragline silk during fibre spinning
Spider silks are some of the strongest materials found in nature1,2. Achieving the high tensile strength and elasticity of the dragline of orb-weaving spiders, such as Nephila clavipes3,4,5, is aExpand
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Disturbed microtubule function and induction of micronuclei by chelate complexes of mercury(II).
Interactions of mercury(II) with the microtubule network of cells may lead to genotoxicity. Complexation of mercury(II) with EDTA is currently being discussed for its employment in detoxificationExpand
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The conserved C-termini contribute to the properties of spider silk fibroins.
Spider silk fibroins can adopt different structural states at high protein concentrations. They are soluble within the spinning dope of the glands, but readily converted into insoluble polymers uponExpand
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Genotoxicity of inorganic mercury salts based on disturbed microtubule function
This study investigated the hypothesis that the chromosomal genotoxicity of inorganic mercury results from interaction(s) with cytoskeletal proteins. Effects of Hg2+ salts on functional activities ofExpand
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Motor protein-driven unidirectional transport of micrometer-sized cargoes across isopolar microtubule arrays
Conventional kinesin is a motor protein which translocates organelles from cell centre to cell periphery along specialized filamentous tracks, called microtubules. The direction of translocation isExpand
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Conserved C-termini of Spidroins are secreted by the major ampullate glands and retained in the silk thread.
The C-termini of Spidroins produced in the major and minor ampullate glands of spiders are highly conserved. Despite this conservation, no corresponding peptides have been identified in the spinningExpand
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Interaction of metal salts with cytoskeletal motor protein systems.
Interactions of chemicals with the microtubular network of cells may lead to genotoxicity. Micronuclei (MN) might be caused by interaction of metals with tubulin and/or kinesin. The genotoxic effectsExpand
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