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Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
BACKGROUND & AIMS The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes areExpand
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Conditional tetracycline‐regulated expression of TGF‐β1 in liver of transgenic mice leads to reversible intermediary fibrosis
Based on the tetracycline‐regulated gene expression system, a double‐transgenic mouse model for liver fibrosis was established in which the expression of transforming growth factor β1 (TGF‐β1) can beExpand
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Altered subcellular location of phosphorylated Smads in Alzheimer's disease
A number of growth factors and cytokines, such as transforming growth factor beta 1 (TGF‐β1), is elevated in Alzheimer's disease (AD), giving rise to activated intracellular mitogenic signalingExpand
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The effects of pulsed ultraviolet light, cold atmospheric pressure plasma, and gamma-irradiation on the immunoreactivity of soy protein isolate
Abstract This study investigates the effect of nonthermal processing technologies on soy immunoreactivity. Soy protein isolate was treated with pulsed ultraviolet (PUV) light, direct and remote coldExpand
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Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet
BackgroundProliferation of oval cells, the bipotent precursor cells of the liver, requires impeded proliferation and loss of hepatocytes as well as a specific micro-environment, provided by adjacentExpand
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Inducible neuronal expression of transgenic TGF‐β1 in vivo: dissection of short‐term and long‐term effects
Various chronic neurological diseases are associated with increased expression of transforming growth factor‐beta1 (TGF‐β1) in the brain. TGF‐β1 has both neuroprotective and neurodegenerativeExpand
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Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice
Humanized tumor mice (HTM) were generated by the co-transplantation of human hematopoietic stem cells and human breast cancer cells overexpressing HER2 into neonatal NOD-scid IL2Rγnull (NSG) mice.Expand
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Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver.
Glutamine synthetase (GS) has long been known to be expressed exclusively in pericentral hepatocytes most proximal to the central veins of liver lobuli. This enzyme as well as its peculiarExpand
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TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I.
BACKGROUND & AIMS Adverse alcohol effects in the liver involve oxidative metabolism, fat deposition and release of fibrogenic mediators, including TGF-beta. The work presents an assessment of liverExpand
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