• Publications
  • Influence
Inflammatory Cell Migration into the Central Nervous System: A Few New Twists on an Old Tale
Understanding the mechanisms of leukocyte trafficking into the brain might provide insights into how to modulate pathologic immune responses or enhance host protective mechanisms in neuroinflammatoryExpand
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The expression and function of chemokines involved in CNS inflammation.
Chemokines and their receptors have principal roles in leukocyte trafficking under normal physiological and pathological conditions. The differential expression of the chemokine system in differentExpand
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Vertebrobasilar dolichoectasia diagnosed by magnetic resonance angiography and risk of stroke and death: a cohort study.
OBJECTIVE There are only limited epidemiological studies evaluating the association between vertebrobasilar dolichoectasia (VBD) and outcomes. This study was designed to elucidate the outcome andExpand
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Development and Characterization of a Novel Human In Vitro Blood-Nerve Barrier Model Using Primary Endoneurial Endothelial Cells
There are phenotypic and functional differences between vascular endothelium from different tissues and between microvascular and macrovascular endothelial cells (ECs) from the same tissue.Expand
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Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration
Endothelial cells that functionally express blood brain barrier (BBB) properties are useful surrogates for studying leukocyte-endothelial cell interactions at the BBB. In this study, we compared twoExpand
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Determinants of CCL5-driven mononuclear cell migration across the blood–brain barrier. Implications for therapeutically modulating neuroinflammation
Chemokine receptors and adhesion molecules are used selectively for the transmigration of leukocytes across the blood-brain barrier (BBB) during neuroinflammation. We established an activated inExpand
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Inflammatory neuropathies: pathology, molecular markers and targets for specific therapeutic intervention
  • E. Ubogu
  • Medicine
  • Acta Neuropathologica
  • 12 August 2015
Inflammatory neuropathies encompass groups of heterogeneous disorders characterized by pathogenic immune-mediated hematogenous leukocyte infiltration of peripheral nerves, nerve roots or both, withExpand
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“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop
Small blood vessels (generally <100 μm in internal diameter) contribute to fundamental physiological processes and pathological events, but may not necessarily garner the attention associated withExpand
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αMβ2‐integrin‐intercellular adhesion molecule‐1 interactions drive the flow‐dependent trafficking of Guillain–Barré syndrome patient derived mononuclear leukocytes at the blood–nerve barrier in vitro
  • N. Yosef, E. Ubogu
  • Biology, Medicine
  • Journal of cellular physiology
  • 1 December 2012
The mechanisms of hematogenous leukocyte trafficking at the human blood–nerve barrier (BNB) are largely unknown. Intercellular adhesion molecule‐1 (ICAM‐1) has been implicated in the pathogenesis ofExpand
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An Immortalized Human Blood-Nerve Barrier Endothelial Cell Line for In Vitro Permeability Studies
  • N. Yosef, E. Ubogu
  • Biology, Medicine
  • Cellular and Molecular Neurobiology
  • 1 March 2013
Solute and macromolecular transport studies may elucidate nutritional requirements and drug effects in healthy and diseased peripheral nerves. Endoneurial endothelial cells are specializedExpand
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