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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action.
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
It is proposed that this vesicular synergy between two transmitters is the result of the unbalanced bioenergetics of VAChT, which requires anion co-entry for continuing vesicle filling.
Diverse Psychotomimetics Act Through a Common Signaling Pathway
In mice with a genetic deletion of DAR PP-32 or with point mutations in phosphorylation sites of DARPP-32, the effects of D-amphetamine, LSD, and PCP on two behavioral parameters—sensorimotor gating and repetitive movements—were strongly attenuated.
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
The results suggest that the cortical selectivity in the release of catecholamines, dopamine in particular, induced by the cannabinoid antagonist SR141716A, its procholinergic properties, together with its mild stimulatory effects on serotonin and norepinephrine efflux make similar compounds unique candidates for the treatment of psychosis, affective and cognitive disorders.
Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation
- P. Svenningsson, E. Tzavara, P. Greengard
- Psychology, BiologyThe Journal of Neuroscience
- 11 April 2007
5-HT6 receptor stimulation may be a mechanism initiating some of the biochemical and behavioral outcomes of 5-HT reuptake inhibitors, such as fluoxetine, which indicates that selective 5- HT6 receptor agonists may represent a novel antidepressant drug class.
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Δ‐9‐tetrahydrocannabinol
- D. Hutcheson, E. Tzavara, R. Maldonado
- Biology, PsychologyBritish journal of pharmacology
- 1 December 1998
This model permits an easy quantification of THC abstinence in mice and can be useful for the elucidation of the molecular mechanisms involved in cannabinoid dependence.
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)
- P. Svenningsson, E. Tzavara, J. Witkin, A. Fienberg, G. Nomikos, P. Greengard
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 5 March 2002
It is shown that, in vivo, fluoxetine, given either acutely or chronically, regulates the phosphorylation state of dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) at multiple sites in prefrontal cortex, hippocampus, and striatum.
Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB
CREB-dependent gene transcription is a factor in the onset of behavioral manifestations of opiate dependence and the main symptoms of morphine withdrawal were strongly attenuated.
Adenylyl cyclases: structure, regulation and function in an enzyme superfamily