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Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity.
The results suggest that human dietary PCB exposure might have a negative impact on the sperm chromatin integrity of adult males but additional issues, including differences in the genetic background and lifestyle habits, still need to be elucidated. Expand
Semen Quality and Exposure to Persistent Organochlorine Pollutants
Adult exposure to persistent organochlorine pollutants within the ranges observed in the present study is not likely to cause reduction in sperm concentration or morphology, however, higher exposure may be associated with impaired sperm motility. Expand
Developmental toxicity in mice following paternal exposure to Di-N-butyl-phthalate (DBP).
Paternal DBP exposure may disturb the sex ratio of the offspring, delay female sexual maturation, and deteriorate the sperm quality of F1 generation males. Expand
Semen Quality in Relation to Xenohormone and Dioxin-like Serum Activity Among Inuits and Three European Populations
Background Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. Objectives We analyzed associations between semen characteristics and serum xenoestrogen receptorExpand
Quality control workshops in standardization of sperm concentration and motility assessment in multicentre studies.
It is indicated that training and subsequent follow-up workshops can assure minimum variability among centres in assessments of sperm concentration and motility. Expand
Comparison of the effects of bisphenol a alone and in a combination with X‐irradiation on sperm count and quality in male adult and pubescent mice
BPA exposure significantly reduced sperm count in pubescent males compared to adult mice, with degenerative changes detected in seminiferous epithelium, which may suggest a higher susceptibility of germ cells of younger males to BPA action. Expand
Two generation reproductive and developmental toxicity following subchronic exposure of pubescent male mice to di(2-ethylhexyl)phthalate.
Investigation of potential genotoxic effects induced by subchronic exposure to DEHP in germ cells of male mice in the first period of puberty may suggest that diminished spermaozoa quality induced by DEHP may be coincidental with mutations leading to intrauterine deaths and skeletal abnormalities in the offspring. Expand
[Comparative study of the effect of synthetic pyrethroids on the induction of genetic changes in mice somatic and sex cells depending on the exposure route].
The results showed the difference in the action of the pyrethroids on the genetic material of the tested cells and the effect of the route of exposure, however a substantial increase in the micronuclei frequency in the bone marrow was observed after oral exposure only. Expand
[The effects of di-n-butyl phthalate on the somatic cells of laboratory mice].
Results confirmed that DBP acts as a weak mutagen for DNA of somatic cells, however, following prolonged exposure this compound seems to undergo slower metabolism and was reaching temporarily higher levels in peripheral blood. Expand
Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation.
Both BPA alone and the combined exposure slightly affected postnatal development and combined exposure induced two-fold higher postnatal mortality than BPA the alone, whereas BPA exposure caused reduced body weight and diminished sperm quality in F1 generation. Expand