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Motor impairments and neurochemical changes after unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic system in monkeys
Unilateral lesions of the nigrostriatal dopaminergic system were induced in five monkeys by intranigral injections of the neurotoxin 6-hydroxydopamine. Following the lesion, all monkeys showed aExpand
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Responses of tonically discharging neurons in monkey striatum to visual stimuli presented under passive conditions and during task performance
To test whether the responsiveness of tonically discharging neurons from monkey striatum is dependent on the motor or rewarding features of the conditioned stimuli, we studied the responses of theseExpand
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Responses of tonically discharging neurons in the monkey striatum to primary rewards delivered during different behavioral states
Abstract In the primate striatum, the tonically discharging neurons respond to conditioned stimuli associated with reward. We investigated whether these neurons respond to the reward itself and howExpand
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Neglect of contralateral visual stimuli in monkeys with unilateral striatal dopamine depletion
Unilateral lesions of the nigrostriatal dopaminergic system were induced by injecting 6-hydroxydopamine into the substantia nigra of three monkeys trained to initiate arm movements in response toExpand
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Spatio-temporal and kinematic analysis of pointing movements performed by cerebellar patients with limb ataxia
Abstract Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-stepExpand
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The Use of Advance Information for Motor Preparation in Parkinson's Disease: Effects of Cueing and Compatibility between Warning and Imperative Stimuli
The ability of 13 Parkinsonian patients and 11 age-matched control subjects to process and use two components of the information given prior to a voluntary movement was studied using reaction timeExpand
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Globus Pallidus and motor initiation: the bilateral effects of unilateral quisqualic acid-induced lesion on reaction times in monkeys
The results of many experimental studies have shown that the globus pallidus (GP) is involved in the control of motor activities, particularly during motor execution. Whether or not the GP isExpand
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Responses of Tonic Striatal Neurons to Conditioned Stimuli in Behaving Monkeys
Previous studies have shown that tonically discharging neurons in monkey striatum can be modulated by the onset of external stimuli, which are reliable predictors of a rewarding event. In this study,Expand
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The role of internal pallidal segment on the initiation of a goal directed movement
In monkeys performing a pointing movement, reaction times (RTs) had been studied after permanent exclusion or reversible cooling of the internal pallidal segment. The results show a significantExpand
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