• Publications
  • Influence
(S)NO Signals: Translocation, Regulation, and a Consensus Motif
(Table 1; Stamler et al., 1992b). This is well exemplified Nitric oxide (NO) is a signaling molecule that has capin the immune system in work by DeGroote and Fang tured our imagination. According toExpand
  • 645
  • 19
The cluster glycoside effect.
  • 1,084
  • 10
Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor.
A study of the binding of the Shiga-like toxin 1 (SLT-1) to the P(k) trisaccharide [methyl 4-O-(4-O-alpha-D-galactopyranosyl)-4-O-beta-D- glucopyranoside] and its constituent dissacharides wasExpand
  • 105
  • 6
Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis
Lipopolysaccharides (LPS) and lipooligosaccharides (LOS) are the main lipid components of bacterial outer membranes and are essential for cell viability in most Gram-negative bacteria. Here we showExpand
  • 43
  • 5
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing is initiated by the addition of anExpand
  • 146
  • 4
  • PDF
Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities.
The thermodynamics of binding of a system of plant lectins specific for the oligosaccharide methyl 3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside have been studied calorimetrically. ThisExpand
  • 102
  • 4
On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A
The inhibition of protein−carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of such approaches have been frustrated byExpand
  • 163
  • 4
Structure and energetics of protein-carbohydrate complexes
Abstract During the past year, several new coordinate sets for protein-carbohydrate complexes have appeared. The data fall into two important categories: complexes of lectins other than legume andExpand
  • 237
  • 3
Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.
To investigate the molecular basis of antigenic mimicry by peptides, we studied a panel of closely related mAbs directed against the cell-wall polysaccharide of group A Streptococcus. TheseExpand
  • 120
  • 3