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(S)NO Signals: Translocation, Regulation, and a Consensus Motif
The cluster glycoside effect.
Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor.
A model of SLT-1-membrane interaction is proposed that relies on protein-carbohydrate interaction for specificity and protein-lipid interaction for tight binding and dynamic light scattering studies indicate that carbohydrate binding induces protein aggregation.
On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A
- S. M. Dimick, S. Powell, S. McMahon, D. N. Moothoo, J. Naismith, E. Toone
- Biology, Chemistry
- 14 October 1999
The synthesis of a series of multivalent dendritic saccharides and a biophysical evaluation of their interaction with the plant lectin concanavalin A are reported and a 30-fold enhancement in affinity on a valence-corrected basis is observed.
Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis
- Bidong D. Nguyen, D. Cunningham, R. Valdivia
- BiologyProceedings of the National Academy of Sciences
- 31 May 2011
The findings suggest the presence of an outer membrane quality control system that regulates Chlamydia developmental transition to infectious elementary bodies and highlights the potential application of LpxC inhibitors as unique class of antichlamydial agents.
Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities.
It is shown that, despite their common affinity for the mannose trisaccharide, the three lectins bind oligosaccharides very differently, and solute-solute attractive interactions and configurational entropies were the greatest contributors to enthalpy-entropy compensation.
Structure and energetics of protein-carbohydrate complexes
- E. Toone
- 1 October 1994
A Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Binding
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
- A. Winter-Vann, R. Baron, P. Casey
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 22 March 2005
The identification of a selective small-molecule inhibitor of Icmt, 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide (cysmethynil) is reported, providing a compelling rationale for development of I cmt inhibitors as another approach to anticancer drug development.
2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE ALDOLASES AS CATALYSTS FOR STEREOCONTROLLED CARBON-CARBON BOND FORMATION
- M. C. Shelton, I. Cotterill, Sarah T. A. Novak, Rahib M. Poonawala, S. Sudarshan, E. Toone
- Biology, Chemistry
- 6 March 1996
The 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolases from Pseudomonas putida, Escherichia coli, and Zymomonas mobilis are examined for utility as synthetic reagents and show broad substrate specificity with regard to the electrophilic component.