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A Novel Mammalian Retromer Component, Vps26B
The mammalian retromer protein complex, which consists of three proteins – Vps26, Vps29, and Vps35 – in association with members of the sorting nexin family of proteins, has been implicated in theExpand
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Different Characteristics and Nucleotide Binding Properties of Inosine Monophosphate Dehydrogenase (IMPDH) Isoforms
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide biosynthesis, clustered into macrostructures in response to decreasedExpand
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Intracellular sorting and transport of proteins.
The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to directExpand
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Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.
In mammals there are two ubiquitous, catalytically indistinguishable isoforms of inosine monophosphate dehydrogenase and mutations in the type I isoform, but not type II, cause retina-specificExpand
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Insulin and Oleate Promote Translocation of Inosine‐5′ Monophosphate Dehydrogenase to Lipid Bodies
In the present study we identify inosine‐5′ monophosphate dehydrogenase (IMPDH), a key enzyme in de novo guanine nucleotide biosynthesis, as a novel lipid body‐associated protein. To identify newExpand
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A global analysis of SNX27–retromer assembly and cargo specicity reveals a function in glucose and metal ion transport
In the version of this Article originally published, labels were incorrectly aligned to the blots in Fig. 6c,d. The correct figures are shown below. Furthermore, the middle initial of the authorExpand
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The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity.
Efficient insulin action requires spatial and temporal coordination of signaling cascades. The prototypical insulin receptor substrate, IRS-1 plays a central role in insulin signaling. By subcellularExpand
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Structural and Population-Based Evaluations of TBC1D1 p.Arg125Trp
Obesity is now a leading cause of preventable death in the industrialised world. Understanding its genetic influences can enhance insight into molecular pathogenesis and potential therapeuticExpand
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Review Intracellular sorting and transport of proteins
The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to directExpand
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