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Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse
BackgroundWeight change during chemotherapy is reported to be associated with a worse prognosis in breast cancer patients, both with weight gain and weight loss. However, most studies were conducted… Expand
Changes and predictive and prognostic value of the mitotic index, Ki-67, cyclin D1, and cyclo-oxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy.
The current study expands upon previous work using a database of 710 patients treated with neoadjuvant chemotherapy. First, we studied phenotypic characteristics of tumors before and after… Expand
Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma.
BACKGROUND In a previous phase I clinical trial of dietary methionine (MET) restriction with cystemustine treatment for melanoma or glioma, we determined the optimal MET-free diet duration to be 1… Expand
A New Prognostic Classification After Primary Chemotherapy for Breast Cancer: Residual Disease in Breast and Nodes (RDBN)
Purpose:Several factors have been shown to correlate with prognosis of patients with breast carcinoma. Among the most useful are node involvement, tumor size, and pathologic grade. These factors… Expand
Quality of life after mastectomy with or without immediate breast reconstruction
Mastectomy with immediate breast reconstruction (IBR) is a surgical strategy in breast cancer when breast‐conserving surgery is not an option. There is a lack of evidence showing an advantage of… Expand
Temozolomide and unusual indications: review of literature.
Temozolomide (TMZ) was first known to be useful as a radiosensitiser in both primary brain tumours like glioblastoma multiforme and oligodendroglioma. Later, TMZ proved its efficacy in the treatment… Expand
Importance of metabolic changes induced by chemotherapy on prognosis of early‐stage breast cancer patients: a review of potential mechanisms
- É. Gadéa, E. Thivat, E. Planchat, B. Morio, X. Durando
- Obesity reviews : an official journal of the…
- 1 April 2012
Weight variation has been reported as a side effect of chemotherapy treatment in early breast cancer patients and has been identified as a factor of poor prognosis. Causes of weight variation during… Expand
A methionine-free diet associated with nitrosourea treatment down-regulates methylguanine-DNA methyl transferase activity in patients with metastatic cancer.
BACKGROUND Methionine (MET) depletion used in association with chemotherapy improves the therapeutic index in animal models. This potentiating effect may be due to tumor cell sensitization to… Expand
Prognostic Value of Initial Tumor Parameters After Metastatic Relapse
Classical prognostic factors of breast cancer are correlated to disease-free survival and overall survival (OS); their precise role is less known on metastatic disease. A total of 511 breast cancer… Expand
Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight?
- É. Gadéa, E. Thivat, +8 authors X. Durando
- Chemistry, Medicine
- The Journal of clinical endocrinology and…
CONTEXT Hibernoma is a rare benign tumor histologically similar to brown adipose tissue. Some studies reported weight loss in patients with this tumor; however, the mechanisms have never been… Expand