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Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation
- F. M. Buratti, M. Manganelli, +4 authors E. Funari
- Biology, Medicine
- Archives of Toxicology
- 21 January 2017
The properties of the most frequently detected cyanotoxins (namely, microcystins, nodularins, cylindrospermopsin and neurotoxins) are reviewed, describing for each toxin the available information on producing organisms, biosynthesis/genetic and occurrence with a focus on the toxicological profile. Expand
Human Health Risk Assessment Related to Cyanotoxins Exposure
The actual risky exposure scenarios are identified, toxicologically derived reference values are provided, and open issues and research needs are discussed. Expand
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
It will take at least another 7–9 years for the replacement of the current in vivo animal tests used for the safety assessment of cosmetic ingredients for skin sensitisation and it was confirmed that alternative methods may be able to give hazard information, i.e. to differentiate between sensitisers and non-sensitisers, ahead of 2017. Expand
Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer.
It is indicated that a complex interaction between host factors such as oxidative stress, antioxidant capacity and efficiency of multiple DNA repair pathways underlies the inter-individual variability in GC risk. Expand
CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes.
- F. M. Buratti, M. T. Volpe, A. Meneguz, L. Vittozzi, E. Testai
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 February 2003
The data indicated that CYP1A2 and 2B6 are suggested as possible metabolic biomarkers of susceptibility to OPT toxic effect at the actual human exposure levels, while the role of CYP3A4 is more significant to the low-affinity component of OPT bioactivation. Expand
Review and analysis of occurrence, exposure and toxicity of cyanobacteria toxins in food
No definite conclusion on the health risks for the exposed population could be drawn, however, the possibility of risky exposure is evidenced for fish and shellfish consumers and for blue-green algae supplements (BGAS) as well in relation to MC contamination. Expand
Individual susceptibility and alcohol effects:biochemical and genetic aspects.
The large interethnic and interindividual variability in alcohol-induced toxic effects comes from a combination of genetic and environmental factors, influencing ethanol toxicokinetics. The hepatic… Expand
Early exposure to low doses of atrazine affects behavior in juvenile and adult CD1 mice.
Developmental exposure to non-toxic, environmentally relevant doses of ATZ can produce subtle functional alterations, detectable in juvenile rodents by a detailed behavioral analysis, although further research is needed to elucidate the mechanism through which the effects are induced. Expand
Ostreospis cf. ovata blooms in coastal water: Italian guidelines to assess and manage the risk associated to bathing waters and recreational activities
Ostreopsis cf. ovata is a benthic marine dinoflagellate, which blooms in summer along the coasts of the Mediterranean Sea, including many Italian regions since early 1990s. In tropical areas O. cf.… Expand
MALATHION BIOACTIVATION IN THE HUMAN LIVER: THE CONTRIBUTION OF DIFFERENT CYTOCHROME P450 ISOFORMS
- F. M. Buratti, Alessandra D'Aniello, M. T. Volpe, A. Meneguz, E. Testai
- Chemistry, Medicine
- Drug Metabolism and Disposition
- 1 March 2005
Results suggest that CYP1A2 and 2B6 can be considered as possible metabolic biomarkers of susceptibility to OPT-induced toxic effects at actual human exposure levels, and hypothesized that, independently from the chemical structure, OPTs are bioactivated by the same P450s. Expand