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Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism
Summary The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate,Expand
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Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS.
The newly established hyphenated instrumentation of LC/DAD/SPE/NMR and LC/UV/(ESI)MS techniques have been applied for separation and structure verification of the major known constituents present inExpand
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A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology.
Centralized facilities for genetic engineering, or "biofoundries", offer the potential to design organisms to address emerging needs in medicine, agriculture, industry, and defense. The field hasExpand
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Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impactExpand
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Unprecedented Utilization of Pelargonidin and Indole for the Biosynthesis of Plant Indole Alkaloids
Nudicaulins are a group of indole alkaloid glycosides responsible for the color of yellow petals of Papaver nudicaule (Iceland poppy). The unique aglycone scaffold of these alkaloids attracted ourExpand
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New developments in engineering plant metabolic pathways.
Plants contain countless metabolic pathways that are responsible for the biosynthesis of complex metabolites. Armed with new tools in sequencing and bioinformatics, the genes that encode these plantExpand
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Nudicaulins, yellow flower pigments of Papaver nudicaule: revised constitution and assignment of absolute configuration.
The constitution of the aglycon of nudicaulin has been revised to be a pentacyclic indole alkaloid. The relative and absolute configurations of the two diastereomers, nudicaulins I (3a) and II (3b),Expand
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Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis
Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information is not commonly used to identify novel biosynthesis genes. Here, weExpand
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Occurrence of nudicaulin structural variants in flowers of papaveraceous species.
The intense color of yellow Papaver nudicaule flowers is conferred by the presence of nudicaulins, a group of alkaloids with a unique pentacyclic skeleton composed of an indole ring and aExpand
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Biosynthesis of Nudicaulins: A 13CO2‐Pulse/Chase Labeling Study with Papaver nudicaule
Nudicaulins are unique alkaloids responsible for the yellow color of the petals of some papaveraceaous plants. To elucidate the unknown biosynthetic origin of the skeleton, a 13CO2‐pulse/chaseExpand
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