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Pleiotropic roles of bile acids in metabolism.
This review covers the roles of specific bile acids, synthetic agonists, and their cognate receptors in controlling these diverse functions, as well as their current use in treating human diseases. Expand
LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.
An endogenous mechanism for the preservation of membrane homeostasis during lipid stress is outlined and Lpcat3 is identified as an important mediator of LXR effects on metabolism. Expand
Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma.
- S. O'Sullivan, E. Tarling, A. Bennett, D. Kendall, M. Randall
- Chemistry, Medicine
- Biochemical and biophysical research…
- 25 November 2005
The present results provide strong evidence that THC is a PPARgamma ligand, stimulation of which causes time-dependent vasorelaxation, implying some of the pleiotropic effects of cannabis may be mediated by nuclear receptors. Expand
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
A metabolic-inflammatory circuit that links perturbations in cholesterol biosynthesis with activation of innate immunity is delineated, demonstrating the importance of reprogramming the balance of these two metabolic pathways in vivo. Expand
Role of ABC transporters in lipid transport and human disease
This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders. Expand
Emerging new paradigms for ABCG transporters.
- P. Tarr, E. Tarling, D. Bojanic, P. Edwards, Á. Baldán
- Biology, Medicine
- Biochimica et biophysica acta
- 1 July 2009
Members of the ABCG subfamily of transporters are focused on, which are conserved through evolution in multiple taxa, and participate in multiple cellular homeostatic processes, and functional mutations in some of them have clinical relevance in humans. Expand
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
It is demonstrated that the ability of LXRs to repress inflammatory gene expression in cells and mice derives primarily from their ability to regulate lipid metabolism through transcriptional activation and can occur in the absence of SUMOylation, and identified the putative lipid transporter Abca1 as a critical mediator of LXR's anti-inflammatory effects. Expand
MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor
- T. Q. de Aguiar Vallim, E. Tarling, +4 authors P. Edwards
- Biology, Medicine
- Circulation research
- 7 June 2013
It is shown that activation of the nuclear receptor FXR in vivo increases hepatic levels of miR-144, which in turn lowers hepatic ABCA1 and plasma HDL levels, which together regulate plasma HDL-cholesterol. Expand
Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S]
It is demonstrated that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte differentiation, with increased levels in the outer epidersmis, suggesting a potential role of ABCG 1 in permeability barrier homeostasis. Expand
ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter
- E. Tarling, P. Edwards
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 November 2011
It is demonstrated that ABCG1 is an intracellular sterol transporter that localizes to endocytic vesicles to facilitate the redistribution of specific intrACEllular sterols away from the endoplasmic reticulum (ER). Expand