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Mitochondrial DNA diversity in South America and the genetic history of Andean highlanders.
TLDR
Comparison of among-population variability of mtDNA and Y-chromosome DNA seems to indicate that South America is the only continent where the levels of differentiation are similar for maternal and paternal lineages. Expand
Genetic differentiation in South Amerindians is related to environmental and cultural diversity: evidence from the Y chromosome.
TLDR
A model for the evolution of the male lineages of South Amerindians that involves differential patterns of genetic drift and gene flow is proposed, consistent with the linguistic and cultural diversity of South America, the environmental heterogeneity of the continent, and the available paleoecological data. Expand
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
TLDR
It is shown that ancestry-positive assortative mating permeated Brazilian history and shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes. Expand
Microsatellite loci: determining the genetic variability of Plasmodium vivax
TLDR
The genetic diversity of Plasmodium vivax isolates from different areas in the Brazilian Amazon is described using 11 polymorphic microsatellites and the correlation between microsatellite variation and repeat array length is evaluated. Expand
Influence of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4) Common Polymorphisms on Outcome in Treatment of Melanoma Patients With CTLA-4 Blockade
TLDR
The results suggest that genetic variation in CTLA4 could influence response to CTLA-4 blockade therapy in metastatic melanoma patients, but further studies are necessary to confirm the observed associations. Expand
Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative)
TLDR
The view that ethnoracial self-classification is affected by both genome ancestry and non-biological factors is supported, with most consistent classifications in the extremes of the high and low proportion of African ancestry. Expand
Genetic structure of Quechua-speakers of the Central Andes and geographic patterns of gene frequencies in South Amerindian populations.
TLDR
A sample of 141 Quechua-speaking individuals of the population of Tayacaja was typed for the following 16 genetic systems, finding a longitudinal cline for the AcP1*a and EsD*1 alleles which was interpreted as the result of an ancient longitudinal expansion of a putative ancestral population of modern Amerindians. Expand
Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire
TLDR
It is found that the Native American populations possess distinct ancestral divisions, whereas the mestizo groups were admixtures of multiple Native American communities that occurred before and during the Inca Empire and Spanish rule. Expand
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations
TLDR
Overall, gPMs and mPMs are more frequent among Caucasians, and gUMs among Middle Easterns and Ethiopians, than in other ethnic groups and evolutionary aspects of the CYP2D6 allele distribution appear to support the Great Human Expansion model. Expand
Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity
TLDR
N-acetyltransferase 2 intra-population genetic diversity for Native Americans is higher than East Asians and similar to the rest of the world, and NAT2 variants are homogeneously distributed across native populations of the continent. Expand
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