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Clearance of HCV Improves Insulin Resistance, Beta-Cell Function, and Hepatic Expression of Insulin Receptor Substrate 1 and 2
- T. Kawaguchi, T. Ide, +8 authors M. Sata
- The American Journal of Gastroenterology
- 1 March 2007
It was shown that clearance of HCV improves insulin resistance, beta-cell function, and hepatic IRS1/2 expression, as well as homeostasis model assessment method assessment method. Expand
Expression and Role of Vascular Endothelial Growth Factor in Liver Regeneration After Partial Hepatectomy in Rats
- E. Taniguchi, S. Sakisaka, K. Matsuo, K. Tanikawa, M. Sata
- Chemistry, Medicine
- The journal of histochemistry and cytochemistry…
- 1 January 2001
The results suggest that VEGF promotes proliferation of hepatocytes through reconstruction of liver sinusoids by proliferation of sinusoidal endothelial cells, which point to a new therapeutic strategy, the use of V EGF and other hepatocyte growth factors in fulminant or severe acute hepatitis. Expand
Expression of cyclooxygenase‐2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
The present study is the first to demonstrate a high expression of COX‐2 in well‐differentiated HCC and a low expression in advanced HCC, in contrast to its continuous expression during colorectal carcinogenesis. Expand
Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.
- T. Kawaguchi, Takafumi Yoshida, +14 authors M. Sata
- Biology, Medicine
- The American journal of pathology
- 1 November 2004
HCV infection changes a subset of hepatic molecules regulating glucose metabolism, and a possible mechanism is that HCV core-induced SOCS3 promotes proteosomal degradation of IRS1 and IRS2 through ubiquitination. Expand
Vascular endothelial growth factor in patients with rheumatoid arthritis.
Serum concentration of VEGF was examined in patients with RA, osteoarthritis, systemic lupus erythematosus, SLE, systemic sclerosis and control subjects to suggest that V EGF is involved in the pathogenesis of RA and that measurement of serum concentration ofVEGF is a noninvasive, useful method for monitoring the disease activity of RA. Expand
Insulin resistance and chronic liver disease.
- T. Kawaguchi, E. Taniguchi, M. Itou, M. Sakata, S. Sumie, M. Sata
- World journal of hepatology
- 27 May 2011
Increased insulin resistance is frequently associated with chronic liver disease and is a pathophysiological feature of hepatogenous diabetes. Distinctive factors including hepatic parenchymal cell… Expand
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma.
The findings indicate that the increased expression of Angiopoietin-1 and Angiopeetin-2 play a critical role in the process of vascular development in HCC. Expand
Dipeptidyl peptidase-4: a key player in chronic liver disease.
- M. Itou, T. Kawaguchi, E. Taniguchi, M. Sata
- Biology, Medicine
- World journal of gastroenterology
- 21 April 2013
The impact of D PP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor are discussed. Expand
Involvement of p21WAF1/Cip1, p27Kip1, and p18INK4c in troglitazone‐induced cell‐cycle arrest in human hepatoma cell lines
Findings suggested that p21, p27, and p18 might be involved in troglitazone‐induced cell‐cycle arrest in human hepatoma cells. Expand
Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis
Substantial alteration in the TJ protein occurs predominantly in bile ducts in PBC and in hepatocytes in PSC, suggesting increasedParacellular permeability along different paracellular routes for bile regurgitation in these chronic cholestatic liver diseases. Expand