• Publications
  • Influence
The trabecular meshwork outflow pathways: structural and functional aspects.
  • E. Tamm
  • Chemistry, Medicine
  • Experimental eye research
  • 30 April 2009
TLDR
The architecture of the TM outflow pathways and consequently outflow resistance appear to be modulated by contraction of ciliary muscle and scleral spur cells, which have the ultrastructural characteristics of mechanosensory nerve endings. Expand
Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling
TLDR
The phenotype of Sox11-deficient mice suggests a prime function for Sox11 in tissue remodeling and identifies SOX11 as a potentially mutated gene in corresponding human malformation syndromes. Expand
Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork.
TLDR
Connective tissue growth factor overexpression in the mouse eye increases intraocular pressure and leads to optic nerve damage, and the effects of CTGF on IOP appear to be caused by a modification of the TM actin cytoskeleton. Expand
Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure
TLDR
It is shown that pathologic changes in hemizygous Rs1h−/Y male mice are evenly distributed across the retina, apparently contrasting with the macula-dominated features in human, suggesting that both conditions are a disease of the entire retina affecting the organization of the retinal cell layers as well as structural properties of theretinal synapse. Expand
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage
The Sox10 transcription factor is required to maintain as well as specify glial identity, adding new causes for the neuropathies associated with SOX10 mutations.
The role of TGF-β in the pathogenesis of primary open-angle glaucoma
TLDR
The available data strongly indicate that TGF-β2 is a key player contributing to the structural changes in the extracellular matrix (ECM) of the trabecular meshwork and optic nerve head as characteristically seen in POAG. Expand
Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases
  • A. Cvekl, E. Tamm
  • Biology, Medicine
  • BioEssays : news and reviews in molecular…
  • 1 April 2004
TLDR
It is proposed that PAX6 is a key element that synchronizes the complex interaction of cell types of different origin, which are all needed for proper morphogenesis of the anterior eye. Expand
AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach.
TLDR
AlphaB is not essential for normal development of a transparent lens in the mouse, and therefore is more dispensable to the lens than the closely related alphaA-crystallin, which may play a small role in maintaining transparency throughout life. Expand
Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye.
TLDR
The presence of an intrinsic nerve cell plexus that is specifically localized in human eyes in the temporal-central portion of the choroid indicates a functional significance of the nitrergic choroidal innervation for the fovea. Expand
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes.
TLDR
Investigation of the expression of the PG-synthesizing enzymes cyclooxygenase (COX)-1 and -2 found specific loss of COX-2 expression in the nonpigmented secretory epithelium of the ciliary body appears to be linked to the occurrence of POAG and steroid-induced glaucoma. Expand
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