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Structure of GSK3β reveals a primed phosphorylation mechanism
GSK3β was identified as the kinase that phosphorylates glycogen synthase but is now known to be involved in multiple signaling pathways. GSK3β prefers prior phosphorylation of its substrates. WeExpand
Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer*
The p38 signaling pathway is activated in response to cell stress and induces production of proinflammatory cytokines. P38α is phosphorylated and activated in response to cell stress by MKK3 and MKK6Expand
Atomic Structure of Clathrin A β Propeller Terminal Domain Joins an α Zigzag Linker
Clathrin triskelions form the lattice that organizes recruitment of proteins to coated pits and helps drive vesiculation of the lipid bilayer. We report the crystal structure at 2.6 A resolution of aExpand
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells—preliminary comparisons to paclitaxel
(+)–Discodermolide, a sponge–derived natural product, stabilizes microtubules more potently than paclitaxel despite the lack of any obvious structural similarities between the drugs. It competitivelyExpand
Taxanes and other microtubule stabilising agents
Paclitaxel (Taxol®) and docetaxel (Taxotere®) are relatively new drugs used in cancer therapy and have shown great promise in the treatment of a variety of cancers. The taxane therapy, however,Expand
Activating MAP KAP Kinase 2
The crystal structures of MAP KAP kinase 2 in complex with ADP and staurosporine suggest a major reorganization of the glycine-rich loop upon ligand binding. The main determinant for the catalyticExpand
clathrin From the Cover : Peptide-in-groove interactions link target proteins to the beta-propeller of
www.pnas.org/cgi/content/full/97/3/1096#otherarticles This article has been cited by other articles: E-mail Alerts . click here at the top right corner of the article or Receive free email alertsExpand
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