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Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma
TLDR
The autoantigens of a new category of treatment‐responsive paraneoplastic encephalitis are reported, and it is proposed that this category should be combined with existing treatment-responsive encephalopathy categories.
Limbic Encephalitis and Variants: Classification, Diagnosis and Treatment
TLDR
Once considered an extremely rare disorder, almost always related to cancer, and refractory to treatment, limbic encephalitis is now regarded as a relatively frequent disorder, often unrelated to cancer and with clinical-immunologic variants that respond to treatment.
Potassium channel antibodies in two patients with reversible limbic encephalitis
TLDR
It is suggested that patients with limbic symptoms and excessive secretions should be tested for VGKC antibodies, and, if they are present, prompt and effective immunosuppressive treatment should be considered.
Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
TLDR
Findings coupled with recently reported in vitro data showing that antibodies downregulate the levels of NMDA receptors suggest that the antibody immune-response is more relevant than cytotoxic T-cell mechanisms in the pathogenesis of anti-NMDAR-associated encephalitis.
A patient with encephalitis associated with NMDA receptor antibodies
TLDR
Paraneoplastic encephalitis associated with immature teratoma of the ovary and N-methyl-D-aspartate receptor antibodies is associated with prominent autonomic instability requiring intubation and sedation.
Interleukin-6 in neuro-Behçet's disease: association with disease subsets and long-term outcome.
TLDR
CSF IL-6 seems to be a marker of disease activity and long-term outcome for pNB along with CSF cell count and protein levels, and could be used in chronic progressive patients who have normalCSF cell, or protein levels to detect disease activity.
Epigenetics of Multiple Sclerosis: An Updated Review
TLDR
Ongoing efforts in this field are expected to result in characterization of epigenetic factors that can be used in prediction of treatment responsive MS patients, diagnostic screening panels and treatment methods with specific mechanism of action.
Enhanced IL-6 Production in Aquaporin-4 Antibody Positive Neuromyelitis Optica Patients
TLDR
The results suggest that IL-6 is involved in NMO pathogenesis presumably viaAnti-Aqp-4 associated mechanisms, and serum/CSF IL- 6 levels correlated with anti-Aquaporin-4 levels and disease severity of the NMO patients.
Resistance to Experimental Autoimmune Myasthenia Gravis in IL-6-Deficient Mice Is Associated with Reduced Germinal Center Formation and C3 Production1
TLDR
EAMG resistance in IL-6−/− mice was associated with a significant reduction in germinal center formation and decreased serum complement C3 levels, and AChR-specific lymphocyte proliferative response, IFN-γ, and IL-10 production were suppressed.
Paroxysmal attacks in multiple sclerosis
TLDR
It is demonstrated that paroxysmal attacks occur early in the course of the disease, when there is little or no neurologic disability and associated tissue damage.
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