E. Szathmáry

Publications262
h-index48
Citations11,792
Highly Influential Citations536
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The Major Transitions in Evolution
TLDR
This book discusses the origins of societies, development and evolution, and the development of spatial patterns in simple organisms.
The major evolutionary transitions
There is no theoretical reason to expect evolutionary lineages to increase in complexity with time, and no empirical evidence that they do so. Nevertheless, eukaryotic cells are more complex than…
Toward major evolutionary transitions theory 2.0
  • E. Szathmáry
  • Medicine, Biology
    Proceedings of the National Academy of Sciences
  • 2 April 2015
The impressive body of work on the major evolutionary transitions in the last 20 y calls for a reconstruction of the theory although a 2D account (evolution of informational systems and transitions…
Evolution before genes
TLDR
It is discovered that if general conditions are satisfied, the accumulation of adaptations in chemical reaction networks can occur, and only when a chemical reaction network consists of many viable cores, can it be evolvable.
The Origins of Life: From the Birth of Life to the Origin of Language
TLDR
The Origins of Life represents the thinking of two leading scientists on questions that engage us all--how life began and how it gradually evolved from tiny invisible cells into whales and trees and human beings.
Group selection of early replicators and the origin of life.
TLDR
The stochastic corrector model is presented as an alternative resolution of Eigen's paradox and assumes that replicative templates are competing within replicative compartments, whose selective values depend on the internal template composition via a catalytic acid in replication and "metabolism".
Coding coenzyme handles: a hypothesis for the origin of the genetic code.
  • E. Szathmáry
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 November 1993
TLDR
The coding coenzyme handle hypothesis suggests that useful coding preceded translation, and extension of the genetic code proceeded through the take-over of nonsense codons by novel amino acids, related to already coded ones either through precursor-product relationship or physicochemical similarity.
The origin of the genetic code: amino acids as cofactors in an RNA world.
  • E. Szathmáry
  • Biology, Medicine
    Trends in genetics : TIG
  • 1 June 1999
TLDR
Experimental findings, including selection for ribozymes catalyzing peptide-bond formation and those utilizing an amino acid cofactor, hold promise that scenarios of this major transition can be tested.
Real ribozymes suggest a relaxed error threshold
TLDR
It is shown, on the basis of comparative analysis of two extensively mutagenized ribozymes, that with a copying fidelity of 0.999 per digit per replication the phenotypic error threshold rises well above 7,000 nucleotides, which permits the selective maintenance of a functionally rich riboorganism with a genome of more than 100 different genes, the size of a tRNA.
On origin of genetic code and tRNA before translation
TLDR
A new model of tRNA origin is proposed by the gradual, Fibonacci process-like, elongation of a tRNA molecule from a primordial coding triplet and 5'DCCA3' quadruplet to the eventual 76 base-long cloverleaf-shaped molecule.
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