Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
Effects of Moderate Aerobic Exercise Training on Hemorheological and Laboratory Parameters in Ischemic Heart Disease Patients
Regular physical training improved the exercise tolerability of patients with ischemic heart disease and positive changes in laboratory parameters and body weight may indicate better oxidative and inflammatory circumstances and an improved metabolic state.
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart.
Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease.
The results show that resveratrol improved left ventricle diastolic function, endothelial function, lowered LDL-cholesterol level and protected against unfavourable hemorheological changes measured in patients with coronary artery disease (CAD).
The Effects of SGLT2 Inhibitors on Lipid Metabolism
The use of SGLT2 inhibitors were associated with fewer adverse renal outcomes comparing to other diabetic agents, substantiating their renoprotective effect in diabetic patients.
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
It is demonstrated that chronic inhibition of PARP induces long-term favourable changes in the most important signalling pathways related to oxidative stress, which prevents remodelling, preserves systolic function, and delays transition of hypertensive cardiopathy to HF in SHRs.
Regulation of Kinase Cascade Activation and Heat Shock Protein Expression by Poly(ADP-ribose) Polymerase Inhibition in Doxorubicin-induced Heart Failure
- É. Bartha, Izabella Solti, R. Halmosi
- Biology, ChemistryJournal of Cardiovascular Pharmacology
- 1 October 2011
Data suggest that the mode of the cytoprotective action of the PARP inhibitor may include the modulation of kinase pathways and heat shock protein expression.
[The effect of carvedilol on enhanced adp-ribosylation and red blood cell membrane damage caused by free radicals].
The results show that carvedilol can modulate the ROI-induced signaling through poly- and mono-ADP-ribosylation reactions, the NAD+ catabolism in postischemic perfused hearts and has a marked scavenger effect on free radical generator induced red blood cell membrane damage.
Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model
- Adam Riba, L. Deres, B. Sumegi, K. Toth, E. Szabados, R. Halmosi
- Biology, MedicineOxidative Medicine and Cellular Longevity
- 3 October 2017
Results suggest that regulation of stress signaling pathways may also contribute to the beneficial effects of RES in HF, as well as inhibition of prohypertrophic signaling molecules.