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- Publications
- Influence
Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
- E. Szabados, G. M. Fischer, +6 authors B. Sumegi
- Medicine, Chemistry
- Free radical biology & medicine
- 1 February 1999
The short term cardiac side-effects of AZT (3'-azido-3'-deoxythymidine, zidovudine) was studied in rats to understand the biochemical events contributing to the development of AZT-induced… Expand
Effects of Moderate Aerobic Exercise Training on Hemorheological and Laboratory Parameters in Ischemic Heart Disease Patients
- B. Sandor, Alexandra Nagy, +6 authors E. Szabados
- Medicine
- PloS one
- 27 October 2014
Background and Design In this study we set out to determine the effects of long-term physical training on hemorheological, laboratory parameters, exercise tolerability, psychological factors in… Expand
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
- E. Szabados, P. Literati-Nagy, Beatrix Farkas, B. Sumegi
- Biology, Medicine
- Biochemical pharmacology
- 15 April 2000
The protective effect of O-(3-piperidino-2-hydroxy-1-propyl)nicotinic amidoxime (BGP-15) against ischemia-reperfusion-induced injury was studied in the Langendorff heart perfusion system. To… Expand
Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart.
- E. Szabados, G. M. Fischer, F. Gallyas, G. Kispál, B. Sumegi
- Medicine, Chemistry
- Free radical biology & medicine
- 1 November 1999
Poly-ADP-ribose polymerase (PARP) is considered to play an important role in oxidative cell damage. We assumed that ischemia-reperfusion resulting from the increasing reactive oxygen species (ROS)… Expand
Regulation of Kinase Cascade Activation and Heat Shock Protein Expression by Poly(ADP-ribose) Polymerase Inhibition in Doxorubicin-induced Heart Failure
- Eva Bartha, Izabella Solti, +10 authors R. Halmosi
- Biology, Medicine
- Journal of cardiovascular pharmacology
- 1 October 2011
Cardiomyopathy is one of the most severe side effects of the chemotherapeutic agent doxorubicin (DOX). The formation of reactive oxygen species plays a critical role in the development of… Expand
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
- Eva Bartha, Izabella Solti, +9 authors K. Toth
- Medicine
- Cardiovascular research
- 1 August 2009
AIMS
Oxidative stress followed by abnormal signalling can play a critical role in the development of long-term, high blood pressure-induced cardiac remodelling in heart failure (HF). Since oxidative… Expand
The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.
- T. Habon, E. Szabados, +4 authors K. Toth
- Chemistry, Medicine
- Cardiovascular research
- 1 October 2001
OBJECTIVE
Previous studies have reported that the beta and alpha adrenoceptor blocker carvedilol has unique protective effects on free radical-induced myocardial injury. The aim of this study was to… Expand
Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease.
- K. Magyar, R. Halmosi, +7 authors E. Szabados
- Medicine
- Clinical hemorheology and microcirculation
- 2012
Several beneficial effects of resveratrol (RES), a natural antioxidant present in red wine have already been described. The aim of our study was to investigate if RES had a clinically measurable… Expand
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
- A. Pálfi, A. Tóth, +10 authors R. Halmosi
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 July 2006
The inhibition of glycogen synthase kinase-3beta (GSK-3beta) via phosphorylation by Akt or protein kinase C (PKC), or the activation of mitogen-activated protein kinase (MAPK) cascades can play a… Expand
The Role of Akt and Mitogen-Activated Protein Kinase Systems in the Protective Effect of Poly(ADP-Ribose) Polymerase Inhibition in Langendorff Perfused and in Isoproterenol-Damaged Rat Hearts
- A. Pálfi, A. Tóth, +10 authors K. Toth
- Biology, Medicine
- Journal of Pharmacology and Experimental…
- 1 October 2005
Blocking poly(ADP-ribosyl)ation of nuclear proteins protects the heart from ischemia-reperfusion injury. In addition, activation of Akt and mitogen-activated protein kinase (MAPK) cascades also plays… Expand