• Publications
  • Influence
CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore
Kinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to driveExpand
  • 348
  • 46
  • PDF
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
How are signalling molecules organized into different pathways within the same cell? In Drosophila, the inaD gene encodes a protein consisting of five PDZ domains which serves as a scaffold toExpand
  • 619
  • 44
  • PDF
The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL
SUMMARY Drosophila phototransduction is a G protein-coupled, calcium-regulated signaling cascade that serves as a model system for the dissection of phospholipase C (PLC) signaling in vivo. TheExpand
  • 334
  • 32
  • PDF
The Drosophila Trio Plays an Essential Role in Patterning of Axons by Regulating Their Directional Extension
We identified the Drosophila trio gene, which encodes a Dbl family protein carrying two Dbl homology (DH) domains, each of which potentially activates Rho family GTPases. Trio was distributed alongExpand
  • 201
  • 23
Ebola Virus VP40 Drives the Formation of Virus-Like Filamentous Particles Along with GP
ABSTRACT Using biochemical assays, it has been demonstrated that expression of Ebola virus VP40 alone in mammalian cells induced production of particles with a density similar to that of virions. ToExpand
  • 319
  • 20
  • PDF
Synaptic development is controlled in the periactive zones of Drosophila synapses.
A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone,Expand
  • 133
  • 14
O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions.
The O-linked-N-acetylglucosamine (O-GlcNAc) modification of cytoplasmic and nuclear proteins regulates basic cellular functions and is involved in the aetiology of diabetes and neurodegeneration.Expand
  • 127
  • 13
Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
Precise synaptogenesis is crucial to brain development, and depends on the ability of specific partner cells to locate and communicate with one another. Dynamic properties of axonal filopodia duringExpand
  • 150
  • 13
A lysosomal tetraspanin associated with retinal degeneration identified via a genome‐wide screen
The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted aExpand
  • 103
  • 11
  • PDF
Still life, a Protein in Synaptic Terminals of Drosophila Homologous to GDP-GTP Exchangers
The morphology of axon terminals changes with differentiation into mature synapses. A molecule that might regulate this process was identified by a screen of Drosophila mutants for abnormal motorExpand
  • 134
  • 9