• Publications
  • Influence
Leptin and cancer
The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac diseaseExpand
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Function of the IGF-I Receptor in Breast Cancer
  • E. Surmacz
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • 2004
The insulin-like growth factor-I receptor (IGF-IR)3 is a transmembrane tyrosine kinaseregulating various biological processes such as proliferation, survival, transformation,Expand
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Founder mutations in BRCA1 and BRCA2 genes.
BRCA1 and BRCA2 germline mutations contribute to a significant number of familial and hereditary breast and/or ovarian cancers. The proportion of high-risk families with breast and/or ovarian cancerExpand
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  • PDF
Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
Purpose: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether the leptin systemExpand
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Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
BackgroundAdiponectin, a fat tissue-derived adipokine, exhibits beneficial effects against insulin resistance, cardiovascular disease, inflammatory conditions, and cancer. Circulating adiponectinExpand
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miR‐20b modulates VEGF expression by targeting HIF‐1α and STAT3 in MCF‐7 breast cancer cells
MicroRNAs (miRNAs) are small non‐coding RNAs that regulate the expression of different genes, including genes involved in cancer progression. A functional link between hypoxia, a key feature of theExpand
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Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells.
The insulin-like growth factor I receptor (IGF-IR) paracrine or autocrine loop plays an important role in the maintenance of breast cancer growth. Cancer cells contain several-fold higher levels ofExpand
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Association of insulin receptor substrate 1 with simian virus 40 large T antigen.
Mouse embryo cells expressing a wild-type number of insulin-like growth factor I receptors (IGF-IR) (W cells) can be transformed either by simian virus 40 large T antigen (SV40 T) or by overexpressedExpand
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Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.
Insulin receptor substrate 1 (IRS-1) is a major signaling molecule activated by the insulin and insulin-like growth factor I receptors. Recent data obtained in different cell models suggested that inExpand
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Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cells
The pure antiestrogen ICI 182,780 inhibits insulin‐like growth factor (IGF)‐dependent proliferation in hormone‐responsive breast cancer cells. However, the interactions of ICI 182,780 with IGF‐IExpand
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