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Inhibition of mouse alveolar macrophage production of tumor necrosis factor alpha by acute in vivo and in vitro exposure to tobacco smoke.
TLDR
It is concluded that the production of TNF alpha by AM was impaired by smoking via direct action of the factors present in tobacco smoke.
Impaired swallowing reflex in patients with obstructive sleep apnea syndrome.
TLDR
Patients with obstructive sleep apnea syndrome are likely to exhibit an impaired swallowing reflex, probably due to the perturbed neural and muscular function of the upper airways.
Effects of lung volume on airway resistance during induced constriction in papain-treated rabbits.
TLDR
The observation that volume dependence of Raw was less in papain-treated animals is consistent with the hypothesis that papain effects significant changes in the parenchymal attachments, and suggests that both cartilage elasticity and mechanical interdependence are important determinants of airway smooth muscle shortening.
Long-term effects of inhaled anticholinergic drug on lung function, dyspnea, and exercise capacity in patients with chronic obstructive pulmonary disease.
TLDR
The chronic use of an inhaled anticholinergic bronchodilator may provide beneficial improvements in expiratory flow rate, exercise performance, and dyspnea in mild to moderate COPD patients over one year.
The effects of aging on the function of alveolar macrophages in mice
Intercellular adhesion molecule-1 mediates acid aspiration-induced lung injury.
TLDR
The administration of mAbs to ICAM-1 and LFA-1 alpha after HCI instillation partially attenuated HCI-induced responses, suggesting that the ICam-1/LFA- 1 alpha pathway might be involved in the pathogenesis of adult respiratory distress syndrome caused by acid aspiration.
Effect of chronic tobacco smoke exposure on the function of alveolar macrophages in mice.
TLDR
Although the precise mechanisms of these functional changes of the AM by tobacco smoke exposure are not clear, they may have some immunological effects on the alveolar space.
Detection of human T lymphotropic virus type I proviral DNA in patients with diffuse panbronchiolitis
TLDR
HTLV‐I is not the causative virus in the pathogenesis of COPD, IIP bronchiectasis and bronchogenic carcinoma, and there is a likelihood that HTLV‐ I infection is associated with some cases of DPB; however, this association needs further verification.
Antagonism of ICAM-1 attenuates airway and tissue responses to antigen in sensitized rats.
TLDR
The current observations suggest that ICAM-1/LFA-1 alpha pathway is involved in both the early and late responses in a rat model of allergic asthma, indicating that both airway and lung tissues were involved in this mechanism.
ICAM-1 mediates lung leukocyte recruitment but not pulmonary fibrosis in a murine model of bleomycin-induced lung injury.
TLDR
It is suggested that the intercellular adhesion molecule-1/lymphocyte function-associated antigen-1alpha pathway mediates the accumulation of inflammatory cells in the injured lung caused by bleomycin; however, other mechanisms are important for the subsequent development of pulmonary fibrosis.
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