Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans.
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.
A potential role for glycocalyx perturbation in mediating vascular dysfunction during hyperglycemia is indicated, thereby increasing vascular vulnerability and indicating a potential roles for N-acetylcysteine and mannitol infusion.
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria and plasma hyaluronan, a principal glycocalyX constituent, andhyaluronidase were increased in type 1 diabetes.
Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
Type 2 diabetes is associated with glycocalyx perturbation and increased vascular permeability, which are partially restored following sulodexide administration, which is related to type 2 diabetes mellitus.
Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion.
Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability.
The dimension of the endothelial glycocalyx can be measured reproducibly in humans and is related to cardiovascular risk factors.
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.
Volanesorsen lowered triglyceride levels to less than 750 mg per deciliter in 77% of patients with familial chylomicronemia syndrome, and antisense-mediated inhibition of hepatic APOC3 mRNA with volaneorsen led to decreased plasma apolipoprotein C-III and triglyceride Levels.
The endothelial glycocalyx: a potential barrier between health and vascular disease
- M. Nieuwdorp, M. Meuwese, H. Vink, J. Hoekstra, J. Kastelein, E. Stroes
- BiologyCurrent Opinion in Lipidology
- 1 October 2005
Cumulating evidence suggests that an intact glycocalyx protects the vessel wall, whereas disruption of the glycocalyX upon atherogenic stimuli increases vascular vulnerability for atherogenesis.