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Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
TLDR
Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans. Expand
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.
TLDR
A potential role for glycocalyx perturbation in mediating vascular dysfunction during hyperglycemia is indicated, thereby increasing vascular vulnerability and indicating a potential roles for N-acetylcysteine and mannitol infusion. Expand
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.
TLDR
Oral administration of vancomycin significantly impacts host physiology by decreasing intestinal microbiota diversity, bile acid dehydroxylation and peripheral insulin sensitivity in subjects with metabolic syndrome. Expand
Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability.
TLDR
The dimension of the endothelial glycocalyx can be measured reproducibly in humans and is related to cardiovascular risk factors. Expand
Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
TLDR
Type 2 diabetes is associated with glycocalyx perturbation and increased vascular permeability, which are partially restored following sulodexide administration, which is related to type 2 diabetes mellitus. Expand
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
TLDR
Type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria and plasma hyaluronan, a principal glycocalyX constituent, andhyaluronidase were increased in type 1 diabetes. Expand
The endothelial glycocalyx: a potential barrier between health and vascular disease
TLDR
Cumulating evidence suggests that an intact glycocalyx protects the vessel wall, whereas disruption of the glycocalyX upon atherogenic stimuli increases vascular vulnerability for atherogenesis. Expand
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
TLDR
The development of the adult human microbiome is described and how the composition of the gut microbiota changes in response to modulating factors is discussed, which aims to translate these findings into therapeutic pathways for obesity and T2DM in humans. Expand
Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease
TLDR
The endothelial glycocalyx, protecting the vascular wall against atherogenic influents, could be used for cardiovascular risk stratification and new methods to estimate glycocalyX dimension are promising. Expand
Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion.
TLDR
Cholesterol fluxes are quantified in 15 male volunteers and it is shown that TICE is active in humans and may serve as a novel target to stimulate cholesterol elimination in patients at risk for cardiovascular disease. Expand
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