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Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
The identification of mice carrying PMCA mutations that lead to diseases such as hearing loss and ataxia, as well as the corresponding phenotypes of genetically engineered PMCA "knockout" mice further support the concept of specific, nonredundant roles for each Ca( 2+) pump isoform in cellular Ca(2+) regulation.
Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod.
Expression and Secretion of Plasma Membrane Ca2+-ATPase 4a (PMCA4a) during Murine Estrus: Association with Oviductal Exosomes and Uptake in Sperm
The results show for the first time the presence of oviductal exosomes and highlight their role, along with uterosomes and vaginal exosome, in post-testicular sperm acquisition of PMCA4a which is essential for hyperactivated motility and fertility.
Multiple divergent mRNAs code for a single human calmodulin.
Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility.
- E. Strehler, A. G. Filoteo, J. T. Penniston, A. Caride
- BiologyBiochemical Society Transactions
- 1 November 2007
Structural diversity provides functional versatility in the PMCAs, with specific pumps being essential for cochlear hair cell function, sperm motility, feedback signalling in the heart and pre- and post-synaptic Ca(2+) regulation in neurons.
Cell‐specific expression of plasma membrane calcium ATPase isoforms in retinal neurons
- D. Križaj, S. DeMarco, Juliette Johnson, E. Strehler, D. Copenhagen
- BiologyThe Journal of comparative neurology
- 9 September 2002
It is concluded that PMCA isoforms are selectively expressed in retinal neurons and that processes of Ca2+ clearance are different in rod and cone bipolar cells.
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.
Plasma Membrane Ca2+ ATPase Isoform 4b Binds to Membrane-associated Guanylate Kinase (MAGUK) Proteins via Their PDZ (PSD-95/Dlg/ZO-1) Domains*
- Eunjoon Kim, S. DeMarco, S. Marfatia, A. Chishti, M. Sheng, E. Strehler
- BiologyThe Journal of Biological Chemistry
- 16 January 1998
Yeast two-hybrid assays demonstrate a direct physical binding of Ca2+ pump isoform 4b to MAGUKs via their PDZ domains and reveal a novel role of alternative splicing within the family of plasma membrane Ca 2+ pumps.
Bradykinin and ATP Accelerate Ca2+ Efflux from Rat Sensory Neurons via Protein Kinase C and the Plasma Membrane Ca2+ Pump Isoform 4
Calcium pumps of plasma membrane and cell interior.
Understanding the involvement of different Ca2+ pump isoforms in the pathogenesis of disease allows their identification as therapeutic targets for the development of selective strategies to prevent or combat the progression of these disorders.