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The Sequence of the Human Genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was… Expand
A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome
The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome… Expand
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations-a review.
Lung cancer is the leading cause of cancer related deaths in Canada with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Tumor characterization can identify… Expand
The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin‐Induced Ototoxicity in Children With Cancer
Ototoxicity is a debilitating side effect of platinating agents with substantial interpatient variability. We sought to evaluate the association of thiopurine S‐methyltransferase (TPMT) and catechol… Expand
Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model.
BACKGROUND The epidermal growth factor receptor (EGFR) kinase domain T790M (amino acid substitution at position 790 in EGFR from threonine [T] to methionine [M]) mutation in non-small-cell lung… Expand
patient-reported Health Utility Scores (hus) in Non-small Cell Lung Cancer (nsclc) Patients with Epidermal Growth Factor Receptor (egfr) Mutations by Drug Therapy : 88.
Real‐World EQ5D Health Utility Scores for Patients With Metastatic Lung Cancer by Molecular Alteration and Response to Therapy
Introduction Economic analyses of upcoming treatments for lung cancer benefit from real‐world health utility scores (HUSs) in an era of targeted therapy. Methods A longitudinal cohort study at… Expand
Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes
Abstract Twelve new (salicylaldiminato)platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405… Expand
Characterizing the last holdouts
Lung cancer is the most common cause of cancer-related death in the world . Tyrosine kinase inhibitors (TKIs) targeting EGFR, have led to multi-fold improvements in survival for the 15-50% of… Expand