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Impact of KRAS, BRAF, PIK3CA Mutations, PTEN, AREG, EREG Expression and Skin Rash in ≥2nd Line Cetuximab-Based Therapy of Colorectal Cancer Patients
TLDR
It is shown that KRAS-BRAF mutations and EREG expression can be used as biomarkers to further select patients undergoing anti-EGFR treatment. Expand
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
TLDR
It is reported that Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype, which was more resistant to LPS-induced endotoxin shock and to dextran sulfate sodium (DSS)-induced colitis than wild-type mice, whereasAkt1−/− mice were more sensitive. Expand
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC
TLDR
There is substantial discordance in EGFR and K-RAS mutational status between the primary tumours and corresponding metastases in patients with NSCLC and this might have therapeutic implications when treatment with TKIs is considered. Expand
Prognostic Value of the Molecular Detection of Circulating Tumor Cells Using a Multimarker Reverse Transcription-PCR Assay for Cytokeratin 19, Mammaglobin A, and HER2 in Early Breast Cancer
TLDR
The detection of peripheral blood CK19mRNA+ and MGB1m RNA+ cells before adjuvant chemotherapy predicts poor DFS in women with early breast cancer. Expand
Breast cancer during pregnancy: a mini-review.
TLDR
Current evidence suggests that diagnosis may be carried out with limitations regarding staging; surgical treatment may be performed as for the non-pregnant women, while chemotherapy is allowed after the first trimester. Expand
MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer
TLDR
There was a non-significant trend for high expression levels of the microRNAs, miR-21,MiR-210, MiR-221 and mi-222, to be associated with worse patient disease-free and overall survival. Expand
Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential.
TLDR
Two new monoclonal antibodies (Lym-1 and Lym-2), reactive with the cell surface of B-lymphocytes and derived tumors, have been produced using tumor cell nuclei preparations as immunogens and it is determined that both reagents have a relatively large number of antibody binding sites per tumor cell and increased avidity for lymphoma cells when compared to normal and reactive lymph node B-cells. Expand
Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice
TLDR
Akt2 suppression and miR-146a induction promote the M2 macrophage phenotype, resulting in amelioration of acid-induced lung injury, which may be deleterious in septic ARDS because of impaired bacterial clearance. Expand
Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer.
TLDR
In multivariate analysis, the interaction between CK-19 mRNA-positive CTCs and ER status was the strongest independent prognostic factor for reduced DFS and overall survival in patients with ER- negative, triple-negative, and HER2-positive early-stage breast cancer. Expand
Prognostic significance of metastasis-related microRNAs in early breast cancer patients with a long follow-up.
TLDR
The results clearly indicate that deregulation of metastasis-associated miRNAs in primary tumors is associated with clinical outcome in patients with early breast cancer and can differentiate patients with higher risk in well-characterized subgroups. Expand
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