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The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders
The accumulated knowledge has expanded the understanding of the involvement of fatty acids in metabolic processes, thereby enabling the transition from basic exploratory studies to practical issues of application of these biomolecules to CVD treatment.
The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review
The relevance of secretory activity molecules of visceral adipocytes in cardiovascular disease associated abdominal obesity and their molecular genetic characteristics is described.
Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia
- Y. Ragino, V. Vavilin, G. Tolstikov
- Medicine, BiologyBulletin of Experimental Biology and Medicine
- 6 December 2008
Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 µg/kg simvastatin exhibited…
Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia
- Y. Ragino, V. Vavilin, G. Tolstikov
- Medicine, ChemistryBulletin of Experimental Biology and Medicine
- 8 August 2008
Using rabbit model of experimental hypercholesterolemia we showed that the hypocholesterolemic effect of simvaglisin, a complex preparation containing simvastatin and glycyrrhizic acid, in doses…
Effects of Simvaglyzin and Atorvaglyzin on the Expression of 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase in Rat Liver
- E. Stakhneva, V. Vavilin, Y. Ragino, O. Safronova, A. Shintyapina, M. V. Ivanova
- Biology, ChemistryBulletin of Experimental Biology and Medicine
- 24 November 2013
Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with…
The cholesterol lowering properties of the complex compound simvastatin with glycyrrhizic acid (simvaglyzin) in experimental models
The data suggest pharmacological synergism attributed to the SV-GA complex formation and increased safety of the resultant complex compared with a parent compound.
The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin
- O. Rymar, S. Voevoda, E. Shakhtshneider, E. Stakhneva, S. Mustafina, L. Shcherbakova
- MedicineObesity and metabolism
- 24 July 2021
In women 25–45 years old, low and high PRL values are more often associated with metabolic ill health, and when deciding on the treatment of women with non-tumor etiology hyperprolactinemia, it is important to assess the metabolic status.
A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis
This proteomic study identifies the proteins present in atherosclerotic plaques of coronary arteries by comparing their proteomes at three different stages of plaque development during coronary atherosclerosis.
[Blood Levels of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Men from Different Population Groups and Its Relation to Unfavorable Long-Term Prognosis].
Investigating blood levels of proprotein convertase subtilisin/kexin type 9 in men from different population subgroups, their associations with cardiovascular risk factors and with unfavorable 7-years long-term prognosis indicates that in men increase of blood level of PCSK9 protein by 1ng/ml independently of other parameters increases relative risk of cardiovascular death during following 7 years by 1%.
Association of Level of Proprotein Convertase Subtilisin/Kexin Type 9 with Intima-Media Thickness in Patients with Familial Hypercholesterolemia
- K. Benimetskaya, Y. Ragino, M. Voevoda
- MedicineBulletin of Experimental Biology and Medicine
- 18 July 2017
It was shown that PCSK9 levels positively correlate with carotid artery intima-media thickness in patients with familial hypercholesterolemia.