E. Spina

Publications316
h-index62
Citations11,702
Highly Influential Citations427
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Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.
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Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
Our objective was to determine the influence of cytochrome P450 (CYP) 2C9 and CYP2C19 genetic polymorphisms on warfarin dose requirement and metabolic clearance.
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Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update.
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Metabolic drug interactions with newer antipsychotics: a comparative review.
TLDR
Differences in the interaction potential among the novel antipsychotics currently available may be predicted based on their metabolic pathways, and the clinical relevance of these interactions should be interpreted in relation to the relative width of their therapeutic index.
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Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone
TLDR
It is indicated that the CYP2D6 polymorphism may be of limited importance for the clinical outcome of the treatment of schizophrenic patients on monotherapy with risperidone, and the lack of relationship between the genotype and the sum of ris peridone and 9-OH-risperidones indicates that the cytochrome P450 2D6 genotype is oflimited importance.
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CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants:
a first step towards subpopulation‐specific dosages
TLDR
This review aimed to provide distinct dose recommendations for antidepressants based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP1C19 to provide a useful complementation to clinical monitoring and therapeutic drug monitoring.
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Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.
TLDR
The results indicate that the Ethiopian population has a unique relative distribution of the CYP2C9 alleles, which is not similar to any other ethnic group hitherto described.
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Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes.
TLDR
It is suggested that CYP2D6 plays a predominant role in (+)-9-hydroxylation of risperidone, the major metabolic pathway in clinical conditions, whereas CYP3A catalyzes the formation of the (-)- 9-hydroxymetabolite.
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Clobazam Therapeutic Drug Monitoring: A Comprehensive Review of the Literature With Proposals to Improve Future Studies
TLDR
Future clobazam TDM studies need to use trough concentrations after steady state has been reached and standardization and more studies of C/D ratios from clobzam and other drugs can be helpful to move TDM forward.
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Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics
TLDR
The results suggest that plasma clozapine levels are correlated with clinical effects, although there is considerable variability in the response achieved at any given drug concentration.
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