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Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements
TLDR
It is shown that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids, implying a relationship betweenCRISPR and immunity against targeted DNA.
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Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria
TLDR
The SRSRs are widespread among the various physiological and phylogenetic groups, probably being present in all the Archaea and hyperthermophilic Bacteria, in at least some members of the cyanobacteria and proteobacteria lineages, as well as in the two subgroups of Gram-positive bacteria (the low and high GC content groups).
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Clinical benefit associated with idiotypic vaccination in patients with follicular lymphoma.
TLDR
Idiotypic vaccination induced a specific immune response in the majority of patients with follicular lymphoma and was associated with a dramatic and highly statistically significant increase in disease-free survival, the first formal demonstration of clinical benefit associated with the use of a human cancer vaccine.
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Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma.
TLDR
This manufacturing process is reliable and robust, the manufacturing time from biopsy to vaccine is <12 weeks and the expression and purification of antigens require only 2 weeks, providing 50- to 1000-fold higher yields than alternative plant expression methods.
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Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer
TLDR
Loss of FHIT protein is correlated with a high proliferation and low apoptotic index in tumor cells, and is an independent prognostic indicator for the clinical outcome in patients with these tumors.
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Quantitative detection of Helicobacter pylori in water samples by real‐time PCR amplification of the cag pathogenicity island gene, cagE
Aims:  A new real‐time PCR assay that simultaneously amplifies a 102‐bp fragment of the cagE gene from Helicobacter pylori and a new internal positive control containing a specific sequence of the…
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PTEN Protein Expression Correlates With PTEN Gene Molecular Changes but not With VEGF Expression in Astrocytomas
TLDR
Loss of PTEN expression is frequent in high-grade astrocytomas, but not in grade 2 tumors, and correlates with PTEN deletion and loss of chromosome 10, while PTEN immunoreactivity does not correlate with VEGF expression in astroCytomas when similar areas are considered.
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The identification and isolation of CTCs: A biological Rubik's cube.
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Evaluation of the baculovirus and E.coli-expressed non-structural (NS) proteins of bluetongue virus (BTV) as antigen in an indirect or competition ELISA to differentiate infected from vaccinated…
TLDR
Evaluation of the baculovirus and E.coli-expressed non-structural proteins of bluetongue virus (BTV) as antigen in an indirect or competition ELISA to differentiate infected from vaccinated animals.
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Prolonged idiotypic vaccination against follicular lymphoma
TLDR
Prolonged idiotypic vaccination with the soluble protein Id-KLH + GM-CSF formulation is safe and well tolerated.
View on Taylor & Francis
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